CST1 information

CST1
Identifiers
Aliases	CST1, cystatin SN
External IDs	OMIM: 123855; HomoloGene: 88653; GeneCards: CST1; OMA:CST1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	23,751,268 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; parotid gland; ; olfactory zone of nasal mucosa; ; tibial nerve; ; Skeletal muscle tissue of biceps brachii; ; prostate; ; tonsil; ; endometrium; ; appendix; ; right uterine tube;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; protein binding; protease binding; cysteine-type endopeptidase inhibitor activity;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of peptidase activity; detection of chemical stimulus involved in sensory perception of bitter taste; negative regulation of cysteine-type endopeptidase activity; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	1469
	n/a
	ENSG00000170373
	n/a
	P01037
	n/a
	NM_001898
	n/a
	NP_001889
	n/a
	Wikidata
View/Edit Human

Cystatin-SN is a protein that in humans is encoded by the CST1 gene.^[3]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid.^[3]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170373 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CST1 cystatin SN".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170373 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: CST1 cystatin SN".

CST1 information

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CST1

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Cystatin

CST5