Global InformationCPA superfamily information
The cation:proton antiporter (CPA) superfamily is a superfamily of transport proteins named after one of its constituent members, the monovalent cation:proton antiporter-2 (CPA2).[1]
CPA1 was considered a member of the superfamily until 2010, when it was discovered to in fact be a member of the VIC superfamily.[2][3][4] As of April 2016, the CPA superfamily consists of four members:
- Monovalent cation:proton antiporter-2 family[1]
- Malonate:Sodium symporter family[5]
- Putative sulfate exporter family[6]
- Sodium-transporting carboxylic acid decarboxylase family[7]
Structural variation exists between families. For example, members of the CPA2 family are between 300 and 900 amino acyl residues (aas) in length and exhibit 10 to 14 transmembrane segments (TMSs), while members of the MSS family are shorter than 300 aas and exhibit 4 to 7 TMSs.
- ^ a b "2.A.37 The Monovalent Cation:Proton Antiporter-2 (CPA2) Family". Transporter Classification Database.
- ^ Chen, Jonathan S.; Reddy, Vamsee; Chen, Joshua H.; Shlykov, Maksim A.; Zheng, Wei Hao; Cho, Jaehoon; Yen, Ming Ren; Saier, Milton H. Jr. (2011). "Phylogenetic Characterization of Transport Protein Superfamilies: Superiority of SuperfamilyTree Programs over Those Based on Multiple Alignments". Journal of Molecular Microbiology and Biotechnology. 21 (3–4): 83–96. doi:10.1159/000334611. PMC 3290041. PMID 22286036.
- ^ Koishi, Ryuta; Xu, Haoxing; Ren, Dejian; Navarro, Betsy; Spiller, Benjamin W.; Shi, Qing; Clapham, David E. (2004-03-05). "A superfamily of voltage-gated sodium channels in bacteria". The Journal of Biological Chemistry. 279 (10): 9532–9538. doi:10.1074/jbc.M313100200. ISSN 0021-9258. PMID 14665618.
- ^ "1.A.1 The Voltage-gated Ion Channel (VIC) Superfamily". Transporter Classification Database. Retrieved 2016-04-05.
- ^ "2.A.70 The Malonate:Na+ Symporter (MSS) Family". Transporter Classification Database.
- ^ "2.A.98 The Putative Sulfate Exporter (PSE) Family". Transporter Classification Database.
- ^ "3.B.1 The Na+-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family". Transporter Classification Database.