CMV polyradiculomyelopathy information

CMV polyradiculomyelopathy
CMV polyradiculomyelopathy
Specialty	Neurology

CMV polyradiculomyelopathy (PRAM) is one of the five distinct neurological syndromes caused by CMV in HIV/AIDS. It causes subacute ascending lower extremity weakness with paresthesias and radicular pain, hyporeflexia or areflexia,^[1] and urinary retention.^[2] It has been suggested that CMV polyradiculomyelopathy should be treated with both ganciclovir and foscarnet in patients who develop the disease while taking either of these drugs.^[3]

^ Cohen, B. A.; McArthur, J. C.; Grohman, S.; Patterson, B.; Glass, J. D. (1 March 1993). "Neurologic prognosis of cytomegalovirus polyradiculomyelopathy in AIDS". Neurology. 43 (3, Part 1): 493–9. doi:10.1212/WNL.43.3_Part_1.493. PMID 8383823. S2CID 27051898.
^ Guiot, HM; Pita-García, IL; Bertrán-Pasarell, J; Alfonso, G (December 2006). "Cytomegalovirus polyradiculomyelopathy in AIDS: a case report and review of the literature". Puerto Rico Health Sciences Journal. 25 (4): 359–62. PMID 17550105.
^ Reiss, Carol (2008). Neurotropic Viral Infections. Cambridge University Press. p. 355. ISBN 9781139474160.

[1] Cohen, B. A.; McArthur, J. C.; Grohman, S.; Patterson, B.; Glass, J. D. (1 March 1993). "Neurologic prognosis of cytomegalovirus polyradiculomyelopathy in AIDS". Neurology. 43 (3, Part 1): 493–9. doi:10.1212/WNL.43.3_Part_1.493. PMID 8383823. S2CID 27051898.

[2] Guiot, HM; Pita-García, IL; Bertrán-Pasarell, J; Alfonso, G (December 2006). "Cytomegalovirus polyradiculomyelopathy in AIDS: a case report and review of the literature". Puerto Rico Health Sciences Journal. 25 (4): 359–62. PMID 17550105.

[3] Reiss, Carol (2008). Neurotropic Viral Infections. Cambridge University Press. p. 355. ISBN 9781139474160.