CILP information

CILP
Identifiers
Aliases	CILP, CILP-1, HsT18872, cartilage intermediate layer protein
External IDs	OMIM: 603489; MGI: 2444507; HomoloGene: 2679; GeneCards: CILP; OMA:CILP - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	65,211,473 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,187,887 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; tendon of biceps brachii; ; synovial joint; ; pericardium; ; subcutaneous adipose tissue; ; skin of hip; ; thoracic diaphragm; ; gallbladder; ; decidua; ; tibia;
	Top expressed in
	ankle; ; intercostal muscle; ; sciatic nerve; ; lip; ; soleus muscle; ; epithelium of lens; ; esophagus; ; medial head of gastrocnemius muscle; ; temporal muscle; ; thoracic diaphragm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide diphosphatase activity; alkaline phosphatase activity; extracellular matrix structural constituent;
Cellular component	extracellular region; extracellular matrix; extracellular exosome; extracellular space; collagen-containing extracellular matrix;
Biological process	negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of gene expression; dephosphorylation; negative regulation of SMAD protein signal transduction; cellular response to transforming growth factor beta stimulus;
	Sources:Amigo / QuickGO
Orthologs
	8483
	214425
	ENSG00000138615
	ENSMUSG00000042254
	O75339
	Q66K08
	NM_003613
	NM_173385; NM_001364527
	NP_003604
	NP_775561; NP_001351456
	Wikidata
View/Edit Human	View/Edit Mouse

Cartilage intermediate layer protein 1 is a protein that in humans is encoded by the CILP gene.^[5]^[6]^[7]

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage. The C-terminal 460 amino acids of the protein show 90% similarity to the pig ectonucleotide pyrophosphohydrolase NTPPHase; this region is preceded by a furin protease consensus cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138615 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042254 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lorenzo P, Neame P, Sommarin Y, Heinegard D (Oct 1998). "Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase". J Biol Chem. 273 (36): 23469–75. doi:10.1074/jbc.273.36.23469. PMID 9722584.
^ Lorenzo P, Bayliss MT, Heinegard D (Oct 1998). "A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age". J Biol Chem. 273 (36): 23463–8. doi:10.1074/jbc.273.36.23463. PMID 9722583.
^ ^a ^b "Entrez Gene: CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138615 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042254 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9722584-5] Lorenzo P, Neame P, Sommarin Y, Heinegard D (Oct 1998). "Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase". J Biol Chem. 273 (36): 23469–75. doi:10.1074/jbc.273.36.23469. PMID 9722584.

[pmid9722583-6] Lorenzo P, Bayliss MT, Heinegard D (Oct 1998). "A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age". J Biol Chem. 273 (36): 23463–8. doi:10.1074/jbc.273.36.23463. PMID 9722583.

[entrez-7] "Entrez Gene: CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase".

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