regulation of G2/M transition of mitotic cell cycle
smoothened signaling pathway
motile cilium assembly
centrosome duplication
centriole assembly
positive regulation of non-motile cilium assembly
non-motile cilium assembly
positive regulation of centriole elongation
positive regulation of establishment of protein localization
negative regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
55835
219103
Ensembl
ENSG00000151849
ENSMUSG00000064128
UniProt
Q9HC77
Q569L8
RefSeq (mRNA)
NM_018451
NM_001014996
RefSeq (protein)
NP_060921
NP_001014996 NP_001390462 NP_001390463
Location (UCSC)
Chr 13: 24.88 – 24.92 Mb
Chr 14: 56.76 – 56.81 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Centromere protein J is a protein that in humans is encoded by the CENPJ gene.[5][6] It is also known as centrosomal P4.1-associated protein (CPAP). During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein.
The Drosophila ortholog, sas-4, has been shown to be a scaffold for a cytoplasmic complex of Cnn, Asl, CP-190, tubulin and D-PLP (similar to the human proteins PCNT and AKAP9). These complexes are then anchored at the centriole to begin formation of the centrosome.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000151849 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000064128 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hung LY, Tang CJ, Tang TK (Oct 2000). "Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex". Molecular and Cellular Biology. 20 (20): 7813–25. doi:10.1128/MCB.20.20.7813-7825.2000. PMC 86375. PMID 11003675.
^"Entrez Gene: CENPJ centromere protein J".
^Gopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith AH, Megraw TL, Nicastro D, Gygi SP, Agard DA, Avidor-Reiss T (2011). "Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome". Nature Communications. 2: 359. Bibcode:2011NatCo...2..359G. doi:10.1038/ncomms1367. PMC 3677532. PMID 21694707.
Centromere protein J is a protein that in humans is encoded by the CENPJ gene. It is also known as centrosomal P4.1-associated protein (CPAP). During...
been found in patients with cancer or graft-versus-host disease. CENPE CENPJ CENPT GRCh38: Ensembl release 89: ENSG00000117724 – Ensembl, May 2017 GRCm38:...
Fanconi anemia. Nine new genes that influence bone strength. Mutation of CENPJ models Seckel syndrome. SPNS2 is important in mammalian immune system function...
type 13, which includes skeletal abnormalities and immunodeficiency. CENPF CENPJ CENPT GRCh38: Ensembl release 89: ENSG00000138778 – Ensembl, May 2017 GRCm38:...
Radial glial cell via disrupting the cilia and centrosome localization of CENPJ and the Intraflagellar transport protein 88 (IFT88), which are required...
Global Information
