CACYBP information

CACYBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X5M, 2A25, 2A26
Identifiers
Aliases	CACYBP, GIG5, S100A6BP, SIP, PNAS-107, calcyclin binding protein
External IDs	OMIM: 606186; MGI: 1270839; HomoloGene: 7649; GeneCards: CACYBP; OMA:CACYBP - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	175,012,027 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	160,040,445 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; pons; ; postcentral gyrus; ; entorhinal cortex; ; superior frontal gyrus; ; middle temporal gyrus; ; Brodmann area 46; ; Brodmann area 23; ; orbitofrontal cortex; ; ventricular zone;
	Top expressed in
	primitive streak; ; abdominal wall; ; tail of embryo; ; mandibular prominence; ; genital tubercle; ; maxillary prominence; ; somite; ; yolk sac; ; arcuate nucleus; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein homodimerization activity; protein domain specific binding; ubiquitin protein ligase binding; tubulin binding; S100 protein binding;
Cellular component	nuclear envelope lumen; extracellular exosome; beta-catenin destruction complex; nucleus; nucleoplasm; neuron projection; cell body; cytoplasm; cytosol; SCF ubiquitin ligase complex;
Biological process	cardiac muscle cell differentiation; positive regulation of DNA replication; human ageing; negative regulation of cell death; cellular response to calcium ion; heart development; response to growth hormone; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	27101
	12301
	ENSG00000116161
	ENSMUSG00000014226
	Q9HB71
	Q9CXW3
	NM_014412; NM_001007214
	NM_009786
	NP_001007215; NP_055227
	NP_033916
	Wikidata
View/Edit Human	View/Edit Mouse

Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene.^[5]^[6]^[7]

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116161 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000014226 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Matsuzawa SI, Reed JC (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Molecular Cell. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. PMID 11389839.
^ Matsuzawa S, Li C, Ni CZ, Takayama S, Reed JC, Ely KR (January 2003). "Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)". The Journal of Biological Chemistry. 278 (3): 1837–40. doi:10.1074/jbc.M210263200. PMID 12421809.
^ ^a ^b "Entrez Gene: CACYBP calcyclin binding protein".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116161 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000014226 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11389839-5] Matsuzawa SI, Reed JC (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Molecular Cell. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. PMID 11389839.

[pmid12421809-6] Matsuzawa S, Li C, Ni CZ, Takayama S, Reed JC, Ely KR (January 2003). "Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)". The Journal of Biological Chemistry. 278 (3): 1837–40. doi:10.1074/jbc.M210263200. PMID 12421809.

[entrez-7] "Entrez Gene: CACYBP calcyclin binding protein".

CACYBP information

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