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Medical condition
Bullous keratopathy
Other names
Pseudophakic bullous keratopathy (PBK)
Bullous keratopathy is a condition that occurs in the cornea
Specialty
Ophthalmology
Bullous keratopathy, also known as pseudophakic bullous keratopathy (PBK), is a pathological condition in which small vesicles, or bullae, are formed in the cornea due to endothelial dysfunction.
In a healthy cornea, endothelial cells keeps the tissue from excess fluid absorption, pumping it back into the aqueous humor. When affected by some reason, such as Fuchs' dystrophy or a trauma during cataract removal, endothelial cells suffer mortality or damage.[1] The corneal endothelial cells normally do not undergo mitotic cell division, and cell loss results in permanent loss of function. When endothelial cell counts drop too low, the pump starts failing to function and fluid moves anterior into the stroma and epithelium. The excess fluid precipitates swelling of the cornea. As fluid accumulates between the basal epithelium cells, blister like formations form (bullae) and they undergo painful ruptures releasing their fluid content to the surface. These characteristic malformations disrupt vision and create pain sensations.
^Stuart AJ, Virgili G, Shortt AJ (2016). "Descemet's membrane endothelial keratoplasty versus Descemet's stripping automated endothelial keratoplasty for corneal endothelial failure". Cochrane Database Syst Rev (3): CD012097. doi:10.1002/14651858.CD012097.
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tissue. The most common indication in this category is pseudophakic bullouskeratopathy, followed by keratoconus, corneal degeneration, keratoglobus and...
based expansion is controversial. For endothelial diseases, such as bullouskeratopathy, cadaver corneal endothelial precursor cells have been proven to...
findings are very similar to those seen in pseudophakic/ aphakic bullouskeratopathy. The appearance of the cornea is similar to that in congenital glaucoma...
associated with transient or permanent cloudy vision (pseudophakic bullouskeratopathy); displacement or dislocation of the IOL implant; unplanned high...
to heal. They are used in the treatment of conditions including bullouskeratopathy, dry eyes, corneal abrasions and erosion, keratitis, corneal edema...
deeper incisions. At first successful, Sato's technique resulted in bullouskeratopathy in up to 70% of patients related to endothelial damage. In 1974,...
sunflower and palm oils. Corneas of patients with keratoconus and bullouskeratopathy have increased levels of malondialdehyde, according to one study...
glaucoma may occur due to vitreous prolapse. Retinal detachment Aphakic bullouskeratopathy Aphakia can be corrected by wearing glasses or contact lenses, by...
bluish appearance. This will eventually involve the whole cornea. Bullouskeratopathy (blisters in the cornea) may also form, leading to nonhealing and...
dystrophy Posterior polymorphous corneal dystrophy Pseudophakic bullouskeratopathy Iridocorneal endothelial syndrome A minor variation to DMEK is the...
transplantation. The initial surgery was performed for pseudophakic bullouskeratopathy. Though donor eyes of all age groups were used in the initial PDEK...
bioreactor is inevitable to ensure appropriate properties of the graft. Bullouskeratopathy that is characterized by corneal stromal edema related to cell loss...
"Increased expression of tenascin-C-binding epithelial integrins in human bullouskeratopathy corneas". J. Histochem. Cytochem. 49 (11): 1341–50. doi:10.1177/002215540104901102...
glaucoma, and long-term hydroxychloroquine treatment can cause vortex keratopathy and maculopathy. While most pregnancies have positive outcomes, there...
distichia, corneal dystrophy, and keratoconjunctivitis sicca. Florida keratopathy an eye condition characterized by the presence of multiple spots within...
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