Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Bryostatins are a group of macrolide lactones from (bacterial symbionts of) the marine organism Bugula neritina that were first collected and provided to JL Hartwell’s anticancer drug discovery group at the National Cancer Institute (NCI) by Jack Rudloe.[1] Bryostatins are potent modulators of protein kinase C. They have been studied in clinical trials as anti-cancer agents, as anti-AIDS/HIV agents and in people with Alzheimer's disease.
^Halford B (24 October 2011). "The Bryostatins' Tale". Chemical and Engineering News. 89 (43): 10–17. doi:10.1021/cen-v089n043.p010.
Bryostatins are a group of macrolide lactones from (bacterial symbionts of) the marine organism Bugula neritina that were first collected and provided...
called bryostatins can be extracted from the marine bryozoan Bugula neritina. In 2001 pharmaceutical company GPC Biotech licensed bryostatin 1 from Arizona...
than was previously achieved. For example, total syntheses of roxaticin, bryostatin and cryptocaryol were accomplished via double Krische allylation of 1...
myricitrin, gossypol. Other PKCIs : Verbascoside, BIM-1, Ro31-8220. Bryostatin 1 can act as a PKC inhibitor; It was investigated for cancer. Tamoxifen...
Endobugula sertula, produces the bryostatins, a group of around twenty bioactive natural products. The bryostatins are under investigation for their...
cancer, anti-inflammatory use and pain. One class of these agents are bryostatin-like compounds, under investigation as anti-cancer therapy.[citation needed]...
discovery that Bryostatin-1 can be used to treat latent HIV infection and formed the basis for clinical trials on the use of Bryostatin as a latent infection-reversing...
Bugula neritina attracted interest as a source of cytotoxic chemicals, bryostatins, under clinical investigation as anti-cancer agents. It was first collected...
carbonyl-olefin metathesis in their preparation of the C-ring fragment of bryostatin 1 In 2012, the Lambert group has reported a ring-opening metathesis of...
elucidation of numerous marine natural products such as the anticancer agent bryostatin, the insecticidal and antifungal jaspamide, diazonamide A and B, and many...
dissoluta), eleutherobin (from the coral Erythropodium caribaeorum), and the bryostatins (from the bryozoan Bugula neritina). Natural products sometimes have...
doi:10.1016/j.tet.2011.10.026 Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity Paul A. Wender, Jeremy...
derivative of a dolastatin 10, a compound made by Dolabella auricularia. Bryostatins were first isolated from Bryozoa. Salinosporamides are derived from Salinispora...
development of a synthetically accessible protein kinase C activator with bryostatin-like activity. Journal of the American Chemical Society. 2009 Jun 10;131(22):7573-9...
Bugula neritina used by the National Cancer Institute (NCI) to develop the bryostatin family of drugs used for treatment of cancer, HIV, Alzheimer's disease...
enantioselectively, moieties found in products such as phorboxazole and bryostatin 1. Although the groups of E. Tagliavini[who?] and K. Mikami[who?] reported...
relationship with the bryozoan Bugula neritina. Certain antineoplastic agents, bryostatins 4 and 5, have been extracted from Aplidium californicum and are being...
1998). "Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A". The...
"Identifying bryostatins and potential precursors from the bryozoan 'Bugula neritina'", Natural Product Research 19.5 (2005) 467–1 Halford, B. "The Bryostatins' Tale"...
total synthesis of complex natural products, culminating in his work on bryostatins. Keck named several compounds after Merle Haggard. Gary Keck was a Fellow...
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