crystal structure of biotin carboxylase domain of acetyl-coenzyme a carboxylase from saccharomyces cerevisiae in complex with soraphen a
Identifiers
Symbol
Biotin_carb_C
Pfam
PF02785
InterPro
IPR005482
SCOP2
1dv1 / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
In enzymology, a biotin carboxylase (EC 6.3.4.14) is an enzyme that catalyzes the chemical reaction
ATP + biotin-carboxyl-carrier protein + CO2 ADP + phosphate + carboxybiotin-carboxyl-carrier protein
The three substrates of this enzyme are ATP, biotin-carboxyl-carrier protein (BCCP), and CO2, whereas its three products are ADP, phosphate, and carboxybiotin-carboxyl-carrier protein.
The systematic name of this enzyme class is biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming). This enzyme is also called biotin carboxylase (component of acetyl CoA carboxylase). This enzyme participates in fatty acid biosynthesis. This enzyme participates in fatty acid biosynthesis by providing one of the catalytic functions of the Acetyl-CoA carboxylase complex. As previously mentioned, after the carboxybiotin product is formed, the carboxyltransferase unit of the complex will transfer the activated carboxy group from BCCP to Acetyl-CoA, forming a malonate analog known as malonyl-CoA. Malonyl-CoA serves as the primary carbon donor in fatty acid biosynthesis, followed by a series of reduction and dehydration reactions to remove the acyl group.[1]
^Engelking, Larry R. (2015-01-01), Engelking, Larry R. (ed.), "Chapter 56 - Fatty Acid Biosynthesis", Textbook of Veterinary Physiological Chemistry (Third Edition), Boston: Academic Press, pp. 358–364, ISBN 978-0-12-391909-0, retrieved 2021-10-18
and 19 Related for: Biotin carboxylase information
In enzymology, a biotincarboxylase (EC 6.3.4.14) is an enzyme that catalyzes the chemical reaction ATP + biotin-carboxyl-carrier protein + CO2 ⇌ {\displaystyle...
mitochondrial protein containing a biotin prosthetic group, requiring magnesium or manganese and acetyl-CoA. Pyruvate carboxylase was first discovered in 1959...
the carbon dioxide carrier in carboxylation reactions. Biotin is a coenzyme for five carboxylase enzymes, which are involved in the catabolism of amino...
syndrome Biotin is a coenzyme for five carboxylases in the human body (propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, pyruvate carboxylase, and...
carboxybiotin throughout the ATP-dependent carboxylation by biotin-dependent carboxylases. The biotin carboxyl carrier protein is an Acetyl CoA subunit that...
Holocarboxylase synthetase (biotin—(propionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)), also known as protein—biotin ligase, is a family of enzymes...
Multiple carboxylase deficiency is a form of metabolic disorder involving failures of carboxylation enzymes. The deficiency can be in biotinidase or holocarboxylase...
still have normal carboxylase activity if they ingest adequate amounts of biotin. The standard treatment regimen calls for 5–10 mg of biotin per day. Biotinidase...
including Acetyl-CoA carboxylase, Methylcrotonyl-CoA carboxylase, Propionyl-CoA carboxylase, and Pyruvate carboxylase require biotin as a cofactor. These...
enzymes, known as carboxylases, are important in the processing of fats, carbohydrates, and proteins. Biotin is attached to these carboxylase enzymes through...
Acetyl-CoA carboxylase 1 also known as ACC-alpha or ACCa is an enzyme that in humans is encoded by the ACACA gene. Acetyl-CoA carboxylase (ACC) is a complex...
in the biotin-dependent enzymes acetyl-CoA carboxylase (ACC), propionyl-CoA carboxylase (PCCase), pyruvate carboxylase (PC) and urea carboxylase. The large...
the body is unable to use the vitamin biotin effectively. This disorder is classified as a multiple carboxylase deficiency, a group of disorders characterized...
Acetyl-CoA carboxylase 2 also known as ACC-beta or ACC2 is an enzyme that in humans is encoded by the ACACB gene. Acetyl-CoA carboxylase (ACC) is a complex...
commonly recognized by name than by number, such as pantothenic acid (B5), biotin (B7), and folate (B9). Each B vitamin is either a cofactor (generally a...
In enzymology, a urea carboxylase (EC 6.3.4.6) is an enzyme that catalyzes the chemical reaction ATP + urea + HCO3- ⇌ {\displaystyle \rightleftharpoons...
Genes were found in this organism that encode the biotincarboxylase, carboxyl transferase and biotin carboxyl carrier protein. These genes were discovered...
post-translational regulation and allosteric regulation of pyruvate dehydrogenase and carboxylase to maintain and support the partition of pyruvate synthesis and degradation...
Organic prosthetic groups can be covalently bound (e.g., biotin in enzymes such as pyruvate carboxylase). An example of an enzyme that contains a cofactor is...
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