Global InformationBioactive glass S53P4 information
Bioactive glass S53P4 (BAG-S53P4) is a biomaterial consisting of sodium, silicate, calcium and phosphate.[1] S53P4 is osteoconductive and also osteoproductive in the promotion, migration, replication and differentiation of osteogenic cells and their matrix production.[2] In other words, it facilitates bone formation and regeneration (osteostimulation). S53P4 has been proven to naturally inhibit the bacterial growth of up to 50 clinically relevant bacteria strains.[3][4][5][6]
- ^ Cunha MT, Murça MA, Nigro S, Klautau GB, Salles MJ (April 2018). "In vitro antibacterial activity of bioactive glass S53P4 on multiresistant pathogens causing osteomyelitis and prosthetic joint infection". BMC Infectious Diseases. 18 (1). BioMed Central: 157. doi:10.1186/s12879-018-3069-x. PMC 5883601. PMID 29614973.
- ^ Virolainen P, Heikkilä J, Yli-Urpo A, Vuorio E, Aro HT (April 1997). "Histomorphometric and molecular biologic comparison of bioactive glass granules and autogenous bone grafts in augmentation of bone defect healing". Journal of Biomedical Materials Research. 35 (1): 9–17. doi:10.1002/(SICI)1097-4636(199704)35:1<9::AID-JBM2>3.0.CO;2-S. PMID 9104694.
- ^ Zhang D, Leppäranta O, Munukka E, Ylänen H, Viljanen MK, Eerola E, et al. (May 2010). "Antibacterial effects and dissolution behavior of six bioactive glasses". Journal of Biomedical Materials Research. Part A. 93 (2): 475–83. doi:10.1002/jbm.a.32564. PMID 19582832.
- ^ Leppäranta O, Vaahtio M, Peltola T, Zhang D, Hupa L, Hupa M, et al. (February 2008). "Antibacterial effect of bioactive glasses on clinically important anaerobic bacteria in vitro". Journal of Materials Science: Materials in Medicine. 19 (2): 547–51. doi:10.1007/s10856-007-3018-5. PMID 17619981. S2CID 21444777.
- ^ Drago L, De Vecchi E, Bortolin M, Toscano M, Mattina R, Romanò CL (2015). "Antimicrobial activity and resistance selection of different bioglass S53P4 formulations against multidrug resistant strains". Future Microbiology. 10 (8): 1293–9. doi:10.2217/FMB.15.57. PMID 26228640.
- ^ Drago L, Vassena C, Fenu S, De Vecchi E, Signori V, De Francesco R, Romanò CL (2014). "In vitro antibiofilm activity of bioactive glass S53P4". Future Microbiology. 9 (5): 593–601. doi:10.2217/fmb.14.20. PMID 24957087.