The tightly bound complex between barstar and barnase, the ribonuclease barstar inhibits. Barstar is colored by secondary structure and barnase is colored in blue.[1]
Barstar is a small protein synthesized by the bacterium Bacillus amyloliquefaciens. Its function is to inhibit the ribonuclease activity of its binding partner barnase, with which it forms an extraordinarily tightly bound complex within the cell until barnase is secreted.[2] Expression of barstar is necessary to counter the lethal effect of expressed active barnase. The structure of the barnase-barnstar complex is known.[3]
^PDB: 1BRS; Buckle AM, Schreiber G, Fersht AR (August 1994). "Protein-protein recognition: crystal structural analysis of a barnase-barstar complex at 2.0-A resolution". Biochemistry. 33 (30): 8878–8889. doi:10.1021/bi00196a004. PMID 8043575.
^Hartley RW (November 1989). "Barnase and barstar: two small proteins to fold and fit together". Trends in Biochemical Sciences. 14 (11): 450–454. doi:10.1016/0968-0004(89)90104-7. PMID 2696173.
^Buckle AM, Schreiber G, Fersht AR (August 1994). "Protein-protein recognition: crystal structural analysis of a barnase-barstar complex at 2.0-A resolution". Biochemistry. 33 (30): 8878–8889. doi:10.1021/bi00196a004. PMID 8043575.
Barstar is a small protein synthesized by the bacterium Bacillus amyloliquefaciens. Its function is to inhibit the ribonuclease activity of its binding...
amyloliquefaciens, but is lethal to the cell when expressed without its inhibitor barstar. The inhibitor binds to and occludes the ribonuclease active site, preventing...
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