Partially soluble in cold water reacts (decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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BOP (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate) reagent is a reagent commonly used in the synthesis of peptides. Its use is discouraged because coupling using BOP liberates HMPA which is carcinogenic, although for small scale use in an organic laboratory this is not a great disadvantage as it is in large scale industrial usage.
BOP has been used for peptide coupling, synthesis of esters, esterification of carboxylic acids, or as a catalyst.[1][2] This reagent is advantageous in peptide coupling to other derived reagents because there are no side reactions from the dehydration of asparagine or glutamine.[2] In peptide coupling the BOP reagent works well because it forms reactive intermediates which allow for the amines to bond together with little energy loss.[3] In the reduction of carboxylic acids, using the BOP reagent with NaBH4 resulted in high percent yields.[3]
^ abPrasad, KVSRG; Bharathi, K; Haseena, Banu B (5 January 2011). "Applications of Peptide Coupling Reagents- An Update". International Journal of Pharmaceutical Sciences Review and Research. 8 (1): 108–119.
^ abMcGeary, Ross P. (1998-05-14). "Facile and chemoselective reduction of carboxylic acids to alcohols using BOP reagent and sodium borohydride". Tetrahedron Letters. 39 (20): 3319–3322. doi:10.1016/S0040-4039(98)00480-8. ISSN 0040-4039.
BOP (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate) reagent is a reagent commonly used in the synthesis of peptides. Its use...
substitute for the BOPreagent - avoiding the formation of the carcinogenic waste product HMPA. BOPreagent DEPBT, a related reagent that contains no phosphorus-nitrogen...
Look up BOP or bop in Wiktionary, the free dictionary. BOP or Bop may refer to: Bird of prey, eagles, hawks, owls and other raptors Bird-of-paradise,...
are more reactive due to the additional nitrogen. HOAt reagent HOBt reagentBOPreagent PyBOP Albericio, F.; Cases, M.; Alsina, J.; Triolo, S. A.; Carpino...
choice of anion. Phosphonium reagents include PyBOP (HOBt) and PyAOP (HOAt).[citation needed] These reagents form the same active ester species as the carbodiimide...
(3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one) is a peptide coupling reagent used in peptide synthesis. It shows remarkable resistance to racemization...
tautomerizable heterocycle is activated with a phosphonium salt (PyBroP, PyBOP, BroP, or BOP), and subsequent functionalization with either a nucleophile through...
also available. Many specialized methods also yield amides. A variety of reagents, e.g. tris(2,2,2-trifluoroethyl) borate have been developed for specialized...
of Corey and Cheng, and uses 2,5-dimethoxytetrahydrofuran as a starting reagent, with S-proline as an asymmetric catalyst. In 2019, a more effective and...
at the stage of the Corey lactone (1) by reaction with methyl Grignard reagent or trimethylaluminium. The resulting mixture of tertiary carbinols (2)...
type of research.[why?] In Canada, phenacetin is used as a laboratory reagent, and in a few hair dye preparations (as a stabilizer for hydrogen peroxide)...
presence of water can lead to hydrolysis of the aspirin. So, an anhydrous reagent is preferred. Reaction mechanism Formulations containing high concentrations...
common feature was a dissatisfaction with the limitations of bebop, hard bop, and modal jazz, which had developed in the 1940s and 1950s. Each in their...
the original on July 18, 2006. Retrieved July 27, 2006. "BOP Statistics: Inmate Race". www.bop.gov. Archived from the original on July 30, 2019. Retrieved...
elements generates the tetrachloride instead), and constitute an important reagent in the preparation of selenium compounds (e.g. Se7). The corresponding...
amide Retosiban 8 by activating the acid with the peptide coupling reagent PyBOP (benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate)...
Reactor, see: bioreactor, membrane reactor and chemical reactor. Reagent A reagent or reactant is a substance or compound consumed during a chemical...
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