Autosomal dominant nocturnal frontal lobe epilepsy is an epileptic disorder that causes frequent violent seizures during sleep. These seizures often involve complex motor movements, such as hand clenching, arm raising/lowering, and knee bending. Vocalizations such as shouting, moaning, or crying are also common. ADNFLE is often misdiagnosed as nightmares. Attacks often occur in clusters and typically first manifest in childhood. There are four known loci for ADNFLE, three with known causative genes. These genes, CHRNA4, CHRNB2, and CHRNA2, encode various nicotinic acetylcholine receptor α and β subunits.
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Autosomaldominantnocturnalfrontallobeepilepsy is an epileptic disorder that causes frequent violent seizures during sleep. These seizures often involve...
Frontallobeepilepsy (FLE) is a neurological disorder that is characterized by brief, recurring seizures arising in the frontallobes of the brain, that...
retained here for reference. Autosomaldominantnocturnalfrontallobeepilepsy (ADNFLE) is an idiopathic localization-related epilepsy that is an inherited epileptic...
CHRNA4 and CHRNB2, which have been associated as AutosomalDominantNocturnalFrontalLobeEpilepsy (ADNFLE) genes. Both of these nAChR subunits are present...
convulsions. Nocturnalfrontallobeepilepsy, often misdiagnosed as nightmares, was considered to be a parasomnia but later identified to be an epilepsy syndrome...
subunits. Mutations in this gene are associated with autosomaldominantnocturnalfrontallobeepilepsy. It has been discovered that suppression, rather than...
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