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Asprosin information


Fibrillin 1
Identifiers
SymbolFBN1
NCBI gene2200
HGNC3603
OMIM134797
RefSeqNP_000129
UniProtP35555
Other data
LocusChr. 15 q21.1
Search for
StructuresSwiss-model
DomainsInterPro

Asprosin is a protein hormone produced by mammals in (white adipose) tissues that stimulates the liver to release glucose into the blood stream. Asprosin is encoded by the gene FBN1 as part of the protein profibrillin and is released from the C-terminus of the latter by specific proteolysis. In the liver, asprosin activates rapid glucose release via a cyclic adenosine monophosphate (cAMP)-dependent pathway.[1]

  1. ^ Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, et al. (April 2016). "Asprosin, a Fasting-Induced Glucogenic Protein Hormone". Cell. 165 (3): 566–579. doi:10.1016/j.cell.2016.02.063. PMC 4852710. PMID 27087445.

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Asprosin

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Asprosin is a protein hormone produced by mammals in (white adipose) tissues that stimulates the liver to release glucose into the blood stream. Asprosin...

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Blood sugar regulation

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Milewicz DM, Sutton VR, Butte NF, Moore DD, Chopra AR (April 2016). "Asprosin, a Fasting-Induced Glucogenic Protein Hormone". Cell. 165 (3): 566–79....

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Marfan syndrome

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deficient in asprosin, a gluco-regulatory protein hormone which is the C-terminal cleavage product of profibrillin. The levels of asprosin seen in these...

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PTPRD

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orexigenic receptor of asprosin, a hormone that is produced by the C-terminal cleavage of profibrillin from the FBN1 gene. In mice, asprosin acts on an olfactory...

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Chromosome 15

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protein critical to the proper functioning of connective tissue), and asprosin (a small protein produced from part of the transcribed FBN1 gene mRNA)...

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White adipose tissue

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adipocytes of white adipose tissue which also produces another hormone, asprosin. White adipose tissue is most abundant in mammals and its distribution...

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Progeroid syndromes

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Milewicz DM, Sutton VR, Butte NF, Moore DD, Chopra AR (April 2016). "Asprosin, a Fasting-Induced Glucogenic Protein Hormone". Cell. 165 (3): 566–79....

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Signaling peptide receptor

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Antagonists PACAP (6-38) PHI PHM PHV Endogenous Adrenomedullin Apelin Asprosin Bombesin Calcitonin Carnosine CART CLIP DSIP Enteroglucagon Formyl peptide...

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2016 in science

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carbon is even stronger than graphene. 14 April – The discovery of hormone asprosin is reported in Cell. 21 April – BioViva USA reports the first successful...

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