Afucosylated monoclonal antibodies are monoclonal antibodies engineered so that the oligosaccharides in the Fc region of the antibody do not have any fucose sugar units. When antibodies are afucosylated, antibody-dependent cellular cytotoxicity (ADCC) is increased.
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reduce antigen-dependent cellular cytotoxicity. Therefore, afucosylatedmonoclonalantibodies have been designed to recruit the immune system to cancers...
Swiss Federal Institute of Technology in Zurich to develop afucosylatedmonoclonalantibodies; GA101 was one of its lead products when it was acquired by...
Pharmaceuticals business The company developed a method to make afucosylatedmonoclonalantibodies using a CHO cell line in which FUT8 has been knocked out;...
Mogamulizumab, sold under the brand name Poteligeo, is a humanized, afucosylatedmonoclonalantibody targeting CC chemokine receptor 4 (CCR4). The U.S. Food and...
CHO cell line in which FUT8 has been knocked out to make afucosylatedmonoclonalantibodies. GRCh38: Ensembl release 89: ENSG00000033170 – Ensembl, May...
GSK2831781 is a monoclonalantibody being developed by GlaxoSmithKline (GSK) for autoimmune diseases. The antibody targets the T cell activation marker...
for depletion of these cells in eosinophilic disorders by using afucosylatedantibodies. EGF module-containing mucin-like hormone receptor GRCh38: Ensembl...
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