Global InformationAcute posterior multifocal placoid pigment epitheliopathy information
| Acute posterior multifocal placoid pigment epitheliopathy | |
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| Placoid lesions seen on fundal examination in APMPPE | |
| Specialty | Ophthalmology |
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an acquired inflammatory uveitis that belongs to the heterogenous group of white dot syndromes in which light-coloured (yellowish-white) lesions begin to form in the macular area of the retina. Early in the course of the disease, the lesions cause acute and marked vision loss (if it interferes with the optic nerve) that ranges from mild to severe but is usually transient in nature. APMPPE is classified as an inflammatory disorder that is usually bilateral and acute in onset but self-limiting. The lesions leave behind some pigmentation, but visual acuity eventually improves even without any treatment (providing scarring doesn't interfere with the optic nerve).
It occurs equally between men and women with a male to female ratio of 1.2:1. Mean onset age is 27, but has been seen in people aged 16 to 40.[1] It is known to occur after or concurrently with a systemic infection (but not always), showing that it is related generally to an altered immune system. Recurrent episodes can happen, but are extremely rare.[2][3]
- ^ Cite error: The named reference
pmid34524577was invoked but never defined (see the help page). - ^ Comu S, Verstraeten T, Rinkoff JS, Busis NA (May 1996). "Neurological manifestations of acute posterior multifocal placoid pigment epitheliopathy". Stroke. 27 (5): 996–1001. doi:10.1161/01.str.27.5.996. PMID 8623125.
- ^ Jones, Nicholas P (1995). "Acute posterior multifocal placoid pigment epitheliopathy". British Journal of Ophthalmology. 79 (4). BMJ group: 384–389. doi:10.1136/bjo.79.4.384. PMC 505108. PMID 7742290.