regulation of centromeric sister chromatid cohesion
positive regulation of canonical Wnt signaling pathway
positive regulation of epithelial to mesenchymal transition
negative regulation of osteoblast differentiation
odontogenesis
multicellular organism development
mRNA stabilization
maintenance of DNA repeat elements
regulation of Wnt signaling pathway
chondrocyte differentiation involved in endochondral bone morphogenesis
regulation of chondrocyte development
secondary heart field specification
cell population proliferation
negative regulation of canonical Wnt signaling pathway
negative regulation of cell population proliferation
positive regulation of GTPase activity
beta-catenin-TCF complex assembly
Wnt signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
8313
12006
Ensembl
ENSG00000168646
ENSMUSG00000000142
UniProt
Q9Y2T1
O88566
RefSeq (mRNA)
NM_004655 NM_001363813
NM_015732
RefSeq (protein)
NP_004646 NP_001350742
NP_056547
Location (UCSC)
Chr 17: 65.53 – 65.56 Mb
Chr 11: 108.81 – 108.84 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Axin-2, also known as axin-like protein (Axil), axis inhibition protein 2 (AXIN2), or conductin, is a protein that in humans is encoded by the AXIN2 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000168646 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000000142 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mai M, Qian C, Yokomizo A, Smith DI, Liu W (May 1999). "Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24". Genomics. 55 (3): 341–4. doi:10.1006/geno.1998.5650. PMID 10049590.
inhibition protein 2 (AXIN2), or conductin, is a protein that in humans is encoded by the AXIN2 gene. The Axin-related protein, Axin2, presumably plays an...
in PAX9 were highly associated with missing upper lateral incisors. The AXIN2 (AXIS inhibition protein 2) gene is a negative regulator of the Wnt signalling...
Additionally, mutations in the AXIN2 gene have been linked to hyperdontia and other anomalous dental traits. The AXIN2 gene is involved in regulating...
substantial interest in cancer research through its interaction with AXIN1 and AXIN2, which are negative regulators of pro-oncogenic β-catenin signaling. Importantly...
increased Wnt signaling due to mutations the adenomatous polyposis coli (APC), AXIN2, or rarely the beta-catenin genes. Wharton KA Jr, Zimmermann G, Rousset...
have mutations in other genes with function similar to APC such as AXIN1, AXIN2, TCF7L2, or NKD1. Beyond the defects in the Wnt signaling pathway, other...
EDAR, and EDARADD genes. Other genes such as MSX1, PAX9, IRF6, GREM2, AXIN2, LRP6, SMOC2, LTBP3, PITX2, and WNT10B. The WNT10A gene is considered to...
AXIN proteins attract substantial interest in cancer research as AXIN1 and AXIN2 work synergistically to control pro-oncogenic β-catenin signaling. Importantly...
teeth in some human populations (possibly along with the less well studied AXIN2 and MSX1). This gene was found amplified in lung cancer. The amplification...
MSX1 and PAX9 genes which are related to tooth agenesis and mutations in AXIN2 gene which cause oligodontia. MSX1 and PAX9 are necessary transcription...
2020 Winter;13(Suppl1):S47-S52. PMID 33585003; PMCID: PMC7881395. APC and AXIN2 Are Promising Biomarker Candidates for the Early Detection of Adenomas and...
craniofacial birth defects such as cleft lip and palate. These genes include AXIN2, BMP4, FGFR1, FGFR2, FOXE1, IRF6, MAFB (gene), MMP3, MSX1, MSX2 (Msh homeobox...
β-catenin as a result of a complex formation that includes β-catenin, AXIN1, AXIN2, APC (a tumor suppressor gene product), CSNK1A1, and GSK3B. Following phosphorylation...
TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells". Nucleic Acids Res. 31 (9): 2369–80...
Global Information
