negative regulation of fibroblast apoptotic process
negative regulation of apoptotic process
apoptotic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
8539
11800
Ensembl
ENSG00000166181
ENSMUSG00000027193
UniProt
Q9BZZ5
O35841
RefSeq (mRNA)
NM_001142930 NM_001142931 NM_001243747 NM_006595
NM_007466 NM_001305258 NM_001349003
RefSeq (protein)
NP_001136402 NP_001136403 NP_001230676 NP_006586
NP_001292187 NP_031492 NP_001335932
Location (UCSC)
Chr 11: 43.31 – 43.34 Mb
Chr 2: 94.24 – 94.27 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The human gene API5 encodes the protein Apoptosis inhibitor 5.[5][6]
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs. Crystal structure of API5 exhibited the function for protein-protein interaction [7]
Diseases associated with API5 include colon adenocarcinoma, and cervical cancer.
API5 functions in nuclear export of mRNA.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000166181 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027193 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (September 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Research. 57 (18): 4063–9. PMID 9307294.
^"Entrez Gene: API5 apoptosis inhibitor 5".
^Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI (March 2012). "Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules". The Journal of Biological Chemistry. 287 (14): 10727–37. doi:10.1074/jbc.M111.317594. PMC 3322819. PMID 22334682.
^Bong SM, Bae SH, Song B, Gwak H, Yang SW, Kim S, Nam S, Rajalingam K, Oh SJ, Kim TW, Park S, Jang H, Lee BI (2020). "Regulation of mRNA Export Through API5 and Nuclear FGF2 Interaction". Nucleic Acids Res. 48 (11): 6340–6352. doi:10.1093/nar/gkaa335. PMC 7293033. PMID 32383752.
The human gene API5 encodes the protein Apoptosis inhibitor 5. This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after...