ANLN information

ANLN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Y7B, 4XH3, 4XOI
Identifiers
Aliases	ANLN, Scraps, scra, FSGS8, anillin actin binding protein, anillin, actin binding protein
External IDs	OMIM: 616027; MGI: 1920174; HomoloGene: 41281; GeneCards: ANLN; OMA:ANLN - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	36,453,791 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	22,300,484 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; inferior ganglion of vagus nerve; ; C1 segment; ; pars reticulata; ; subthalamic nucleus; ; medulla oblongata; ; internal globus pallidus; ; superior vestibular nucleus; ; Pars compacta; ; pons;
	Top expressed in
	deep cerebellar nuclei; ; endothelial cell of lymphatic vessel; ; pontine nuclei; ; vas deferens; ; dermis; ; secondary oocyte; ; efferent ductule; ; zygote; ; genital tubercle; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; cadherin binding;
Cellular component	cytoplasm; cell cortex; actomyosin contractile ring; cytoskeleton; nucleus; nucleoplasm; actin cytoskeleton; cell cortex region; bleb; cell projection; midbody;
Biological process	cell division; septin ring assembly; glomerular visceral epithelial cell migration; mitotic cytokinesis; cell cycle; regulation of exit from mitosis; hematopoietic progenitor cell differentiation; positive regulation of bleb assembly; actomyosin contractile ring assembly; cortical cytoskeleton organization; septin ring organization; protein localization to mitotic actomyosin contractile ring;
	Sources:Amigo / QuickGO
Orthologs
	54443
	68743
	ENSG00000011426
	ENSMUSG00000036777
	Q9NQW6
	Q8K298
	NM_001284301; NM_001284302; NM_018685
	NM_028390
	NP_001271230; NP_001271231; NP_061155
	NP_082666; NP_001391862
	Wikidata
View/Edit Human	View/Edit Mouse

Anillin is a conserved protein implicated in cytoskeletal dynamics during cellularization and cytokinesis. The ANLN gene in humans and the scraps gene in Drosophila encode Anillin.^[5] In 1989, anillin was first isolated in embryos of Drosophila melanogaster. It was identified as an F-actin binding protein.^[6] Six years later, the anillin gene was cloned from cDNA originating from a Drosophila ovary. Staining with anti-anillin (Antigen 8) antibody showed the anillin localizes to the nucleus during interphase and to the contractile ring during cytokinesis.^[7] These observations agree with further research that found anillin in high concentrations near the cleavage furrow coinciding with RhoA, a key regulator of contractile ring formation.^[8]

The name of the protein anillin originates from a Spanish word, anillo. Anillo means ring and shows that the name anillin references the observed enrichment of anillins at the contractile ring during cytokinesis. Anillins are also enriched at other actomyosin rings, most significantly, those at the leading edge of the Drosophila embryo during cellularization. These actomyosin rings invaginate to separate all nuclei for one another in the syncytial blastoderm.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000011426 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036777 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Piekny AJ, Maddox AS (December 2010). "The myriad roles of Anillin during cytokinesis" (PDF). Seminars in Cell & Developmental Biology. 21 (9): 881–91. doi:10.1016/j.semcdb.2010.08.002. PMID 20732437.
^ Zhang L, Maddox AS (February 2010). "Anillin". Current Biology. 20 (4): R135-6. Bibcode:2010CBio...20.R135Z. doi:10.1016/j.cub.2009.12.017. PMID 20178751.
^ Field CM, Alberts BM (October 1995). "Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex". The Journal of Cell Biology. 131 (1): 165–78. doi:10.1083/jcb.131.1.165. PMC 2120607. PMID 7559773.
^ Piekny AJ, Glotzer M (January 2008). "Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis". Current Biology. 18 (1): 30–6. Bibcode:2008CBio...18...30P. doi:10.1016/j.cub.2007.11.068. PMID 18158243. S2CID 6310134.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000011426 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036777 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Piekny_2010-5] Piekny AJ, Maddox AS (December 2010). "The myriad roles of Anillin during cytokinesis" (PDF). Seminars in Cell & Developmental Biology. 21 (9): 881–91. doi:10.1016/j.semcdb.2010.08.002. PMID 20732437.

[Zhang_2010-6] Zhang L, Maddox AS (February 2010). "Anillin". Current Biology. 20 (4): R135-6. Bibcode:2010CBio...20.R135Z. doi:10.1016/j.cub.2009.12.017. PMID 20178751.

[Field_1995-7] Field CM, Alberts BM (October 1995). "Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex". The Journal of Cell Biology. 131 (1): 165–78. doi:10.1083/jcb.131.1.165. PMC 2120607. PMID 7559773.

[Piekny_2008-8] Piekny AJ, Glotzer M (January 2008). "Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis". Current Biology. 18 (1): 30–6. Bibcode:2008CBio...18...30P. doi:10.1016/j.cub.2007.11.068. PMID 18158243. S2CID 6310134.

ANLN information

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ANLN

Pleckstrin homology domain

Australian Height Datum

KIAA0895