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AGILE is a platform trial for early-phase evaluation of new treatments for SARS-CoV-2 infection.[1][2] The trial platform is a collaboration led by the University of Liverpool, working with the Southampton Clinical Trials Unit, the Liverpool School of Tropical Medicine, the MRC Biostatistics Unit at the University of Cambridge and the National Institute for Health and Care Research (NIHR) Clinical Research Facilities.[3] The AGILE platform is funded by the Medical Research Council, and the Wellcome Trust, with additional funding for specific candidate evaluations from the pharmaceutical industry and Unitaid.[4][5] The Chief Investigator of the trial is Saye Hock Khoo.[6]
^Clinical trial number NCT04746183 for "AGILE: Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 Treatment" at ClinicalTrials.gov
^"About us". The AGILE Clinical Trial Platform. Retrieved 2023-03-27.
^"First patient dosed in latest stage of AGILE COVID-19 drug trial - Articles - Clinical Directorate - University of Liverpool". www.liverpool.ac.uk. Retrieved 2023-03-27.
^Khoo SH, FitzGerald R, Saunders G, Middleton C, Ahmad S, Edwards CJ, et al. (February 2023). "Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial". The Lancet. Infectious Diseases. 23 (2): 183–195. doi:10.1016/S1473-3099(22)00644-2. PMC 9662684. PMID 36272432.
^"£2.2m for Liverpool-led initiative to rapidly identify COVID-19 'game changing' drugs". Unitaid. Retrieved 2023-03-27.
^"The Agile Team". The AGILE Clinical Trial Platform. Retrieved 2023-04-04.
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