ADAMTS2 information

ADAMTS2
Identifiers
Aliases	ADAMTS2, ADAM-TS2, ADAMTS-2, ADAMTS-3, NPI, PC I-NP, PCI-NP, PCINP, PCPNI, PNPI, ADAM metallopeptidase with thrombospondin type 1 motif 2, EDSDERMS
External IDs	OMIM: 604539; MGI: 1347356; HomoloGene: 8597; GeneCards: ADAMTS2; OMA:ADAMTS2 - orthologs
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	50,698,400 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; subcutaneous adipose tissue; ; right lung; ; right coronary artery; ; spleen; ; left coronary artery; ; upper lobe of left lung; ; gastric mucosa; ; myometrium; ; left uterine tube;
	Top expressed in
	ascending aorta; ; aortic valve; ; belly cord; ; body of femur; ; ankle; ; cervix; ; vas deferens; ; skin of abdomen; ; external carotid artery; ; internal carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; peptidase activity; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding;
Cellular component	extracellular region; collagen-containing extracellular matrix; extracellular matrix;
Biological process	collagen catabolic process; protein processing; spermatogenesis; skin development; collagen fibril organization; lung development; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	9509
	216725
	n/a
	ENSMUSG00000036545
	O95450
	Q8C9W3
	NM_021599; NM_014244
	NM_001277305; NM_175643
	NP_055059; NP_067610
	NP_783574
	Wikidata
View/Edit Human	View/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS2) also known as procollagen I N-proteinase (PC I-NP) is an enzyme^[4] that in humans is encoded by the ADAMTS2 gene.^[5]^[6]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036545 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tang BL, Hong W (February 1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Lett. 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461. S2CID 37955930.
^ "Entrez Gene: ADAM metallopeptidase with thrombospondin type 1 motif".
^ Colige A, Nuytinck L, Hausser I, van Essen AJ, Thiry M, Herens C, Adès LC, Malfait F, Paepe AD, Franck P, Wolff G, Oosterwijk JC, Smitt JH, Lapière CM, Nusgens BV (October 2004). "Novel types of mutation responsible for the dermatosparactic type of Ehlers-Danlos syndrome (Type VIIC) and common polymorphisms in the ADAMTS2 gene". J. Invest. Dermatol. 123 (4): 656–63. doi:10.1111/j.0022-202X.2004.23406.x. PMID 15373769.^{[permanent dead link]}

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000036545 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10094461-4] Tang BL, Hong W (February 1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Lett. 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461. S2CID 37955930.

[entrez-5] "Entrez Gene: ADAM metallopeptidase with thrombospondin type 1 motif".

[pmid15373769-6] Colige A, Nuytinck L, Hausser I, van Essen AJ, Thiry M, Herens C, Adès LC, Malfait F, Paepe AD, Franck P, Wolff G, Oosterwijk JC, Smitt JH, Lapière CM, Nusgens BV (October 2004). "Novel types of mutation responsible for the dermatosparactic type of Ehlers-Danlos syndrome (Type VIIC) and common polymorphisms in the ADAMTS2 gene". J. Invest. Dermatol. 123 (4): 656–63. doi:10.1111/j.0022-202X.2004.23406.x. PMID 15373769.^{[permanent dead link]}

ADAMTS2 information

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