dentate gyrus of hippocampal formation granule cell
primary visual cortex
ventricular zone
embryo
tail of embryo
secondary oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
heparin binding
zinc ion binding
endopeptidase activity
metal ion binding
peptidase activity
protein binding
hydrolase activity
metallopeptidase activity
metalloendopeptidase activity
Cellular component
extracellular region
extracellular exosome
extracellular space
extracellular matrix
collagen-containing extracellular matrix
Biological process
vascular endothelial growth factor production
collagen fibril organization
protein processing
proteolysis
collagen biosynthetic process
positive regulation of vascular endothelial growth factor signaling pathway
collagen catabolic process
supramolecular fiber organization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9508
330119
Ensembl
ENSG00000156140
ENSMUSG00000043635
UniProt
O15072
n/a
RefSeq (mRNA)
NM_014243
NM_001081401 NM_177872
RefSeq (protein)
NP_055058
n/a
Location (UCSC)
Chr 4: 72.28 – 72.57 Mb
Chr 5: 89.82 – 90.03 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
A disintegrin and metalloproteinase with thrombospondin motifs 3 is an enzyme that in humans is encoded by the ADAMTS3 gene.[5][6] The protein encoded by this gene is the major procollagen II N-propeptidase.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000156140 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000043635 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tang BL, Hong W (February 1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Letters. 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461. S2CID 37955930.
^ ab"Entrez Gene: ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3".
thrombospondin motifs 3 is an enzyme that in humans is encoded by the ADAMTS3 gene. The protein encoded by this gene is the major procollagen II N-propeptidase...
suffering from respiratory tract disorders shared a mutated variant of gene ADAMTS3 that is typically associated with swelling around the airways. Dogs with...
School of Veterinary Studies has found that a DNA mutation in a gene called ADAMTS3 that is not dependent on skull shape is linked to upper airway syndrome...
1 (mutations in CCBE1) Type 2 (mutations in FAT4) Type 3 (mutations in ADAMTS3) The first recognition of a genetic association was with CCBE1, published...
N-terminal propeptide and the VHD. This cleavage can be performed either by ADAMTS3, plasmin, KLK3/PSA or cathepsin D. With progressing maturation, the affinity...
system. CCBE1 is necessary for the proteolytic activation of VEGF-C by ADAMTS3, which is the main growth factor for the lymphatic system. Hennekam syndrome...
Global Information
