40S ribosomal protein S12 information

RPS12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4V6X, 5A2Q, 5AJ0, 4KZY, 4D61, 5FLX, 4KZX, 4D5L, 4UJD, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS12, S12, ribosomal protein S12
External IDs	OMIM: 603660; MGI: 98105; HomoloGene: 110750; GeneCards: RPS12; OMA:RPS12 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	132,817,564 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	23,663,173 bp
RNA expression pattern
	Top expressed in
	left ovary; ; right ovary; ; gonad; ; lymph node; ; skin of abdomen; ; canal of the cervix; ; skin of leg; ; ectocervix; ; granulocyte; ; right uterine tube;
	Top expressed in
	medial ganglionic eminence; ; lip; ; efferent ductule; ; ventricular zone; ; endocardial cushion; ; embryo; ; embryo; ; dermis; ; atrioventricular valve; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of ribosome; RNA binding;
Cellular component	ribosome; cytoplasm; membrane; intracellular anatomical structure; cytosolic small ribosomal subunit; nucleoplasm; cytosol; Golgi apparatus; intracellular membrane-bounded organelle;
Biological process	SRP-dependent cotranslational protein targeting to membrane; viral transcription; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; translational initiation; protein biosynthesis; rRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	6206
	20042
	ENSG00000112306
	ENSMUSG00000061983
	P25398
	P63323; Q6ZWZ6
	NM_001016
	NM_011295
	NP_001007
	NP_035425
	Wikidata
View/Edit Human	View/Edit Mouse

40S ribosomal protein S12 is a protein that in humans is encoded by the RPS12 gene.^[5]^[6]^[7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112306 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061983 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Herault Y, Michel D, Chatelain G, Brun G (Aug 1991). "cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17". Nucleic Acids Res. 19 (14): 4001. doi:10.1093/nar/19.14.4001. PMC 328500. PMID 1861993.
^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
^ ^a ^b "Entrez Gene: RPS12 ribosomal protein S12".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112306 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061983 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1861993-5] Herault Y, Michel D, Chatelain G, Brun G (Aug 1991). "cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17". Nucleic Acids Res. 19 (14): 4001. doi:10.1093/nar/19.14.4001. PMC 328500. PMID 1861993.

[pmid9582194-6] Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.

[entrez-7] "Entrez Gene: RPS12 ribosomal protein S12".

40S ribosomal protein S12 information

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40S ribosomal protein S12

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