Zinc transporter ZIP6 information

SLC39A6
Identifiers
Aliases	SLC39A6, LIV-1, ZIP6, solute carrier family 39 member 6, LIV1
External IDs	OMIM: 608731; MGI: 2147279; HomoloGene: 8199; GeneCards: SLC39A6; OMA:SLC39A6 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	36,129,385 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	24,736,874 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; hair follicle; ; tibia; ; seminal vesicula; ; gingival epithelium; ; caput epididymis; ; epithelium of lactiferous gland; ; lactiferous duct;
	Top expressed in
	hair follicle; ; superior cervical ganglion; ; saccule; ; primary oocyte; ; supraoptic nucleus; ; condyle; ; decidua; ; molar; ; otic vesicle; ; zygote;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion transmembrane transporter activity; zinc ion transmembrane transporter activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; integral component of plasma membrane; lamellipodium membrane; endoplasmic reticulum; membrane;
Biological process	metal ion transport; zinc ion transmembrane transport; zinc ion transport; zinc ion import across plasma membrane; ion transport; cellular zinc ion homeostasis; transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	25800
	106957
	ENSG00000141424
	ENSMUSG00000024270
	Q13433
	Q8C145
	NM_001099406; NM_012319
	NM_139143
	NP_001092876; NP_036451
	NP_631882
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene.^[5]^[6]^[7]

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).[supplied by OMIM]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141424 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024270 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Taylor KM, Nicholson RI (Mar 2003). "The LZT proteins; the LIV-1 subfamily of zinc transporters". Biochim Biophys Acta. 1611 (1–2): 16–30. doi:10.1016/S0005-2736(03)00048-8. PMID 12659941.
^ Taylor KM, Morgan HE, Johnson A, Hadley LJ, Nicholson RI (Sep 2003). "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters". Biochem J. 375 (Pt 1): 51–9. doi:10.1042/BJ20030478. PMC 1223660. PMID 12839489.
^ ^a ^b "Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141424 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024270 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12659941-5] Taylor KM, Nicholson RI (Mar 2003). "The LZT proteins; the LIV-1 subfamily of zinc transporters". Biochim Biophys Acta. 1611 (1–2): 16–30. doi:10.1016/S0005-2736(03)00048-8. PMID 12659941.

[pmid12839489-6] Taylor KM, Morgan HE, Johnson A, Hadley LJ, Nicholson RI (Sep 2003). "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters". Biochem J. 375 (Pt 1): 51–9. doi:10.1042/BJ20030478. PMC 1223660. PMID 12839489.

[entrez-7] "Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6".

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