Zinc transporter ZIP4 information

SLC39A4
Identifiers
Aliases	SLC39A4, AEZ, AWMS2, ZIP4, solute carrier family 39 member 4
External IDs	OMIM: 607059; MGI: 1919277; HomoloGene: 15638; GeneCards: SLC39A4; OMA:SLC39A4 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,416,844 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,501,584 bp
RNA expression pattern
	Top expressed in
	duodenum; ; mucosa of transverse colon; ; human kidney; ; renal cortex; ; body of stomach; ; left lobe of thyroid gland; ; fundus; ; right ovary; ; right lobe of thyroid gland; ; skin of abdomen;
	Top expressed in
	jejunum; ; duodenum; ; yolk sac; ; ileum; ; choroid plexus of fourth ventricle; ; epithelium of small intestine; ; intestinal villus; ; left lobe of liver; ; right lung lobe; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion transmembrane transporter activity; zinc ion transmembrane transporter activity;
Cellular component	integral component of membrane; endosome; recycling endosome membrane; plasma membrane; membrane; integral component of plasma membrane; cytoplasmic vesicle; apical plasma membrane;
Biological process	metal ion transport; zinc ion transport; ion transport; zinc ion import across plasma membrane; transmembrane transport; signal transduction; cellular zinc ion homeostasis; cellular response to zinc ion starvation;
	Sources:Amigo / QuickGO
Orthologs
	55630
	72027
	ENSG00000147804; ENSG00000285243
	ENSMUSG00000063354
	Q6P5W5
	Q78IQ7
	NM_001280557; NM_017767; NM_130849; NM_001374839
	NM_028064
	NP_001267486; NP_060237; NP_570901; NP_001361768
	NP_082340
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc transporter ZIP4 is a transmembrane protein which in humans is encoded by the SLC39A4 gene. It is associated with acrodermatitis enteropathica.^[5]

^ ^a ^b ^c ENSG00000285243 GRCh38: Ensembl release 89: ENSG00000147804, ENSG00000285243 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063354 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kambe T, Andrews GK (January 2009). "Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations". Mol. Cell. Biol. 29 (1): 129–39. doi:10.1128/MCB.00963-08. PMC 2612479. PMID 18936158.

[refGRCh38Ensembl-1] ENSG00000285243 GRCh38: Ensembl release 89: ENSG00000147804, ENSG00000285243 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063354 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18936158-5] Kambe T, Andrews GK (January 2009). "Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations". Mol. Cell. Biol. 29 (1): 129–39. doi:10.1128/MCB.00963-08. PMC 2612479. PMID 18936158.

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