Whi2 information

Whi2 or Whiskey 2 is a 55 kDa globular,^[1] scaffold protein located to cell periphery^[2] in Saccharomyces cerevisiae, which plays an essential role in regulating stress response pathways, apparently by passing input signals about nutrient availability on to stress responsive elements and autophagy/mitophagy mechanisms. It is encoded by a 1.46 kbp gene located on chromosome 15.^[3] Whi2p shares a conserved BTB structure domain to the family of human potassium channel tetramerization domain proteins (KCTDs).^[4] KCTD family members have been associated with several type of cancers and epilepsy disorders.

^ "Protein Overview: WHI2". YeastRC.org. Retrieved 17 April 2012.
^ Yofe, Ido; Weill, Uri; Meurer, Matthias; Chuartzman, Silvia; Zalckvar, Einat; Goldman, Omer; Ben-Dor, Shifra; Schütze, Conny; Wiedemann, Nils; Knop, Michael; Khmelinskii, Anton; Schuldiner, Maya (April 2016). "One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy". Nature Methods. 13 (4): 371–378. doi:10.1038/nmeth.3795. ISSN 1548-7091. PMC 4869835. PMID 26928762.
^ "WHI2 Summary". YeastGenome.org. Retrieved 4 January 2012.
^ Teng, Xinchen; Dayhoff-Brannigan, Margaret; Cheng, Wen-Chih; Gilbert, Catherine E.; Sing, Cierra N.; Diny, Nicola L.; Wheelan, Sarah J.; Dunham, Maitreya J.; Boeke, Jef D.; Pineda, Fernando J.; Hardwick, J. Marie (December 2013). "Genome-wide Consequences of Deleting Any Single Gene". Molecular Cell. 52 (4): 485–494. doi:10.1016/j.molcel.2013.09.026. ISSN 1097-2765. PMC 3975072. PMID 24211263.

[1] "Protein Overview: WHI2". YeastRC.org. Retrieved 17 April 2012.

[2] Yofe, Ido; Weill, Uri; Meurer, Matthias; Chuartzman, Silvia; Zalckvar, Einat; Goldman, Omer; Ben-Dor, Shifra; Schütze, Conny; Wiedemann, Nils; Knop, Michael; Khmelinskii, Anton; Schuldiner, Maya (April 2016). "One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy". Nature Methods. 13 (4): 371–378. doi:10.1038/nmeth.3795. ISSN 1548-7091. PMC 4869835. PMID 26928762.

[3] "WHI2 Summary". YeastGenome.org. Retrieved 4 January 2012.

[:0-4] Teng, Xinchen; Dayhoff-Brannigan, Margaret; Cheng, Wen-Chih; Gilbert, Catherine E.; Sing, Cierra N.; Diny, Nicola L.; Wheelan, Sarah J.; Dunham, Maitreya J.; Boeke, Jef D.; Pineda, Fernando J.; Hardwick, J. Marie (December 2013). "Genome-wide Consequences of Deleting Any Single Gene". Molecular Cell. 52 (4): 485–494. doi:10.1016/j.molcel.2013.09.026. ISSN 1097-2765. PMC 3975072. PMID 24211263.

Whi2 information

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