Weerman degradation, also named Weerman reaction, is a name reaction in organic chemistry. It is named after Rudolf Adrian Weerman, who discovered it in 1910.[1] In general, it is an organic reaction in carbohydrate chemistry in which amides are degraded by sodium hypochlorite, forming an aldehyde with one less carbon.[2] Some have regarded it as an extension of the Hofmann rearrangement.[3]
^Weerman, R. A. (3 September 2010). "Sur une synthèse d'aldéhydes et de l'indol". Recueil des Travaux Chimiques des Pays-Bas et de la Belgique. 29 (1–2): 18–21. doi:10.1002/recl.19100290104.
^Wang, Zerong (2009). Comprehensive organic name reactions and reagents. Hoboken, N.J.: John Wiley. pp. 2946–2950. ISBN 978-0-471-70450-8.
^Arcus, C. L.; Greenwood, D. B. (1953). "398. The Hofmann reaction with α- and β-hydroxy-amides: reactions of the intermediate isocyanates". Journal of the Chemical Society (Resumed): 1937–1940. doi:10.1039/JR9530001937.
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