WNT2B information

WNT2B
Identifiers
Aliases	WNT2B, WNT13, Wnt family member 2B
External IDs	OMIM: 601968; MGI: 1261834; HomoloGene: 22526; GeneCards: WNT2B; OMA:WNT2B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	112,530,165 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	104,869,237 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; buccal mucosa cell; ; parietal pleura; ; gonad; ; skin of hip; ; optic nerve; ; skin of thigh; ; epithelium of colon; ; right ovary; ; left ovary;
	Top expressed in
	epithelium of female urethra; ; muscle layer of urethra; ; pretectal area; ; muscle layer of ejaculatory duct; ; lamina propria of urethra; ; vagina; ; anterior lobe of prostate; ; lamina propria of vagina; ; pelvic part of vagina; ; muscle layer of seminal vesicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	frizzled binding; signaling receptor binding;
Cellular component	extracellular region; extracellular space; intracellular membrane-bounded organelle; collagen-containing extracellular matrix;
Biological process	cell fate commitment; positive regulation of branching involved in ureteric bud morphogenesis; male gonad development; chondrocyte differentiation; positive regulation of canonical Wnt signaling pathway; iris morphogenesis; cornea development in camera-type eye; cellular response to starvation; hematopoietic stem cell proliferation; lung induction; multicellular organism development; forebrain regionalization; lens development in camera-type eye; neuron differentiation; mesenchymal-epithelial cell signaling; canonical Wnt signaling pathway; Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7482
	22414
	ENSG00000134245
	ENSMUSG00000027840
	Q93097
	O70283
	NM_024494; NM_001291880; NM_004185
	NM_009520
	NP_001278809; NP_004176; NP_078613
	NP_033546
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Wnt-2b (formerly Wnt13^[5]) is a protein that in humans is encoded by the WNT2B gene.^[6]^[7]^[8]

This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternative transcript variants.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134245 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027840 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kubo F, Takeichi M, Nakagawa S (2003). "Wnt2b controls retinal cell differentiation at the ciliary marginal zone". Development. 130 (3): 587–98. doi:10.1242/dev.00244. PMID 12490564. S2CID 6642249.
^ Katoh M, Hirai M, Sugimura T, Terada M (Oct 1996). "Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family". Oncogene. 13 (4): 873–6. PMID 8761309.
^ Katoh M, Kirikoshi H, Saitoh T, Sagara N, Koike J (Sep 2000). "Alternative splicing of the WNT-2B/WNT-13 gene". Biochem Biophys Res Commun. 275 (1): 209–16. doi:10.1006/bbrc.2000.3252. PMID 10944466.
^ ^a ^b "Entrez Gene: WNT2B wingless-type MMTV integration site family, member 2B".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134245 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027840 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Kubo F, Takeichi M, Nakagawa S (2003). "Wnt2b controls retinal cell differentiation at the ciliary marginal zone". Development. 130 (3): 587–98. doi:10.1242/dev.00244. PMID 12490564. S2CID 6642249.

[pmid8761309-6] Katoh M, Hirai M, Sugimura T, Terada M (Oct 1996). "Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family". Oncogene. 13 (4): 873–6. PMID 8761309.

[pmid10944466-7] Katoh M, Kirikoshi H, Saitoh T, Sagara N, Koike J (Sep 2000). "Alternative splicing of the WNT-2B/WNT-13 gene". Biochem Biophys Res Commun. 275 (1): 209–16. doi:10.1006/bbrc.2000.3252. PMID 10944466.

[entrez-8] "Entrez Gene: WNT2B wingless-type MMTV integration site family, member 2B".

WNT2B information

and 9 Related for: WNT2B information

Wnt signaling pathway

WNT2B

Lateral plate mesoderm

Limb bud

Stem cell marker

Didier Stainier

Limb development

Proneural genes

Apical ectodermal ridge