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Von Richter reaction information


Von Richter reaction
Named after Victor von Richter
Reaction type Rearrangement reaction
Identifiers
Organic Chemistry Portal von-richter-reaction

The von Richter reaction, also named von Richter rearrangement, is a name reaction in the organic chemistry. It is named after Victor von Richter, who discovered this reaction in year 1871. It is the reaction of aromatic nitro compounds with potassium cyanide in aqueous ethanol to give the product of cine substitution (ring substitution resulting in the entering group positioned adjacent to the previous location of the leaving group) by a carboxyl group.[1][2][3] Although it is not generally synthetically useful due to the low chemical yield and formation of numerous side products, its mechanism was of considerable interest, eluding chemists for almost 100 years before the currently accepted one was proposed.

  1. ^ V. von Richter (1871). "Untersuchungen über die Constitution der Benzolderivate (p )". Ber. Dtsch. Chem. Ges. 4 (1): 459–468. doi:10.1002/cber.187100401154.
  2. ^ V. von Richter (1871). "Untersuchungen über die Constitution der Benzolderivate". Ber. Dtsch. Chem. Ges. 4 (2): 553–555. doi:10.1002/cber.18710040208.
  3. ^ J. F. Bunnett (1958). "Mechanism and reactivity in aromatic nucleophilic substitution reactions". Quarterly Reviews, Chemical Society. 12 (1): 1–16. doi:10.1039/QR9581200001.

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