Global InformationVenombin A information
| Venombin A | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.74 | ||||||||
| CAS no. | 146240-35-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Venombin A (EC 3.4.21.74, alpha-fibrinogenase, habutobin, zinc metalloproteinase Cbfib1.1, zinc metalloproteinase Cbfib1.2, zinc metalloproteinase Cbfib2, ancrod) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Selective cleavage of Arg- bond in fibrinogen, to form fibrin, and release fibrinopeptide A. The specificity of further degradation of fibrinogen varies with species origin of the enzyme
This enzyme is a thrombin-like enzyme from venoms of snakes of the viper/rattlesnake group. Examples include ancrod and batroxobin, two serine proteases from snakes that have been used in medical preparations.[citation needed]
- ^ Nolan C, Hall LS, Barlow GH (1976). "Ancrod, the coagulating enzyme from Malayan pit viper (Agkistrodon rhodostoma) venom". Part B: Proteolytic Enzymes. Methods in Enzymology. Vol. 45. pp. 205–13. doi:10.1016/s0076-6879(76)45020-6. ISBN 978-0-12-181945-3. PMID 1011992.
- ^ Stocker K, Barlow GH (1976). "The coagulant enzyme from Bothrops atrox venom (Batroxobin)". Part B: Proteolytic Enzymes. Methods in Enzymology. Vol. 45. pp. 214–23. doi:10.1016/s0076-6879(76)45021-8. ISBN 978-0-12-181945-3. PMID 1011993.
- ^ Markland FS, Kettner C, Schiffman S, Shaw E, Bajwa SS, Reddy KN, Kirakossian H, Patkos GB, Theodor I, Pirkle H (March 1982). "Kallikrein-like activity of crotalase, a snake venom enzyme that clots fibrinogen". Proceedings of the National Academy of Sciences of the United States of America. 79 (6): 1688–92. Bibcode:1982PNAS...79.1688M. doi:10.1073/pnas.79.6.1688. PMC 346045. PMID 7043462.
- ^ Simmons G, Bundalian M, Theodor I, Martinoli J, Pirkle H (November 1985). "Action of crotalase, an enzyme with thrombin-like and kallikrein-like specificities, on tripeptide nitroanilide derivatives". Thrombosis Research. 40 (4): 555–61. doi:10.1016/0049-3848(85)90292-0. PMID 2934864.
- ^ Itoh N, Tanaka N, Funakoshi I, Kawasaki T, Mihashi S, Yamashina I (June 1988). "Organization of the gene for batroxobin, a thrombin-like snake venom enzyme. Homology with the trypsin/kallikrein gene family". The Journal of Biological Chemistry. 263 (16): 7628–31. doi:10.1016/S0021-9258(18)68544-8. PMID 3163691.