Protein-coding gene in the species Homo sapiens
VPS29 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W24, 2R17
Identifiers Aliases VPS29 , DC15, PEP11, DC7, VPS29 retromer complex component, retromer complex componentExternal IDs OMIM: 606932; MGI: 1928344; HomoloGene: 9433; GeneCards: VPS29; OMA:VPS29 - orthologs Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.11 Start 110,491,083 bp[1] End 110,502,111 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 122,492,432 bp[2] End 122,503,047 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte tibialis anterior muscle mucosa of ileum smooth muscle tissue myocardium of left ventricle gastric mucosa rectum cardiac muscle tissue of right atrium right coronary artery tibial arteries
Top expressed in otic placode facial motor nucleus saccule barrel cortex yolk sac endocardial cushion endothelial cell of lymphatic vessel atrioventricular valve anterior horn of spinal cord nucleus accumbens
More reference expression data
BioGPS
Gene ontology Molecular function
protein binding
metal ion binding
zinc ion binding Cellular component
late endosome
early endosome
endosome membrane
membrane
intracellular membrane-bounded organelle
cytoplasm
cytosol
retromer complex
retromer, cargo-selective complex
endosome Biological process
protein transport
Wnt signaling pathway
regulation of autophagy
intracellular protein transport
retrograde transport, endosome to Golgi
viral process
endocytic recycling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_001282150
NM_019780
RefSeq (protein) NP_001269079
NP_001334382
Location (UCSC) Chr 12: 110.49 – 110.5 Mb Chr 5: 122.49 – 122.5 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex.[5]
^ a b c GRCh38: Ensembl release 89: ENSG00000111237 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029462 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^ Edgar AJ, Polak JM (November 2000). "Human homologues of yeast vacuolar protein sorting 29 and 35". Biochem. Biophys. Res. Commun . 277 (3): 622–30. doi:10.1006/bbrc.2000.3727. PMID 11062004.
Last Update: 2023-03-04T01:23:02Z
VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29 , a component of the retromer complex. The homologous protein (one that performs...
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Last Update: 2024-05-27T06:11:58Z
SNX6), and a vacuolar protein sorting (Vps) heterotrimer containing Vps26, Vps29 , and Vps35. Although the SNX dimer is required for the recruitment of retromer...
Word Count : 1993
Last Update: 2023-12-20T05:45:36Z
vacuolar protein sorting orthologs, VPS26 and VPS29 . In less common situations, VPS35 can bind VPS26 and VPS29 alone, creating heterodimers. VPS26 binds the...
Word Count : 4050
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