positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
8433
22286
Ensembl
ENSG00000171794
ENSMUSG00000047751
UniProt
Q5T230
Q6J1H4
RefSeq (mRNA)
NM_003577
NM_009482
RefSeq (protein)
NP_003568
NP_033508
Location (UCSC)
Chr 10: 133.23 – 133.23 Mb
Chr 7: 139.52 – 139.53 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Undifferentiated embryonic cell transcription factor 1 is a protein in humans that is encoded by the UTF1 gene.
[5] UTF1, first reported in 1998, is expressed in pluripotent cells including embryonic stem cells and embryonic carcinoma cells.[6] Its expression is rapidly reduced upon differentiation. UTF1 protein is localized to the cell nucleus, where it functions to regulate the pluripotent chromatin state and buffer mRNA levels by promoting degradation of mRNA.[7]
Aberrant expression of UTF1 has also been reported in cervical cancer cells, where the UTF1 gene promoter loses methylation and becomes abnormally expressed compared to normal cervical cells.[8]
In rat testis, UTF1 expression is limited to a subpopulation of early type A spermatogonia.[9] Further, in adult human testis, UTF1 gene and protein expression has been shown to be restricted to the earliest state of spermatogonium.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000171794 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000047751 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Okuda A, Fukushima A, Nishimoto M, Orimo A, Yamagishi T, Nabeshima Y, et al. (April 1998). "UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells". The EMBO Journal. 17 (7): 2019–2032. doi:10.1093/emboj/17.7.2019. PMC 1170547. PMID 9524124.
^Jia J, Zheng X, Hu G, Cui K, Zhang J, Zhang A, et al. (October 2012). "Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning". Cell. 151 (3): 576–589. doi:10.1016/j.cell.2012.09.023. PMC 3575637. PMID 23101626.
^Guenin S, Mouallif M, Deplus R, Lampe X, Krusy N, Calonne E, et al. (August 2012). "Aberrant promoter methylation and expression of UTF1 during cervical carcinogenesis". PLOS ONE. 7 (8): e42704. Bibcode:2012PLoSO...742704G. doi:10.1371/journal.pone.0042704. PMC 3411846. PMID 22880087.
transcription factor 1 is a protein in humans that is encoded by the UTF1 gene. UTF1, first reported in 1998, is expressed in pluripotent cells including...
protein Ubiquitin specific peptidase 54 USP6NL: USP6 N-terminal like protein UTF1: undifferentiated embryonic cell transcription factor 1 VIM-AS1: VIM antisense...