Global InformationUSP27X information
The ubiquitin carboxyl-terminal hydrolase 27 (EC 3.4.19.12), also known as deubiquitinating enzyme 27, ubiquitin thioesterase 27 and USP27X,[1] is a deubiquitinating enzyme which is mainly characterized for cleaving ubiquitin (Ub) from proteins and other molecules. Ubiquitin binds to proteins so as to regulate the degradation of them via the proteasome and lysosome among many other functions.[2]
USP27X is encoded by the ubiquitin specific peptidase 27 X-linked gene, found in chromosome X in region Xp11.23.[3] It is mainly found in the cytosol and nucleus of cells, as well as the nucleoplasm and in vesicles. It is an intracellular protein found in many human tissues with low blood cell specificity.[4]
DUBs belong to the superfamily of proteases enzymes. Proteases can be classified into five different classes depending on the mechanism of catalysis: aspartic, metallo, serine, threonine and cystein proteases.[5]
Cysteine proteases comprise ubiquitin C-terminal hydrolases (UCHs), Machada Josepchin domain proteases (MJDs), ovarian tumour proteases (OTU) and ubiquitin-specific proteases (USPs). USP27X is included in the ubiquitin-specific proteases enzymes.[5]
| Ec | 3.4.19.12 |
| Taxonomic identifier
(assigned by the NCBI) |
9606 |
| Taxonomic lineage | eukaryota → metazoa → chordata → craniata → vertebrata → euteleostomi → mammalia → eutheria → euarchontoglires → primates → haplorrhini → catarrhini → homonidae → homo |
| Length | 1574bp |
| Mass | 49.6299 kDa |
| Gene Location
(in humans) |
|
| Cellular location | nucleus, cytoplasm |
| Databases | accession ID |
| HumanCyc | HS17606 |
| UniProt, nextProt | A6NNY8 |
| HGNC | HGNC:13486 |
| proteomics DB | A6NNY8 |
| biogrid | 133302 |
[1][6][3]
- ^ a b "USP27X - Ubiquitin carboxyl-terminal hydrolase 27 - Homo sapiens (Human) - USP27X gene & protein". www.uniprot.org. Retrieved 2019-10-14.
- ^ "Deubiquitinating enzyme", Wikipedia, 2019-08-23, retrieved 2019-10-12
- ^ a b "Human Gene Database". gene cards. Retrieved 2019-10-12.
- ^ "USP27X". the human protein atlas. Retrieved 2019-10-13.
- ^ a b Nijman, Sebastian M. B.; Luna-Vargas, Mark P. A.; Velds, Arno; Brummelkamp, Thijn R.; Dirac, Annette M. G.; Sixma, Titia K.; Bernards, René (2005-12-02). "A genomic and functional inventory of deubiquitinating enzymes". Cell. 123 (5): 773–786. doi:10.1016/j.cell.2005.11.007. hdl:1874/20959. ISSN 0092-8674. PMID 16325574. S2CID 15575576.
- ^ "proteomic DB". Retrieved 2019-10-17.