UGT8 information

UGT8
Identifiers
Aliases	UGT8, CGT, UGT4, UDP glycosyltransferase 8, GalCer Synthase, Ceramide Galactosyltransferase
External IDs	OMIM: 601291 MGI: 109522 HomoloGene: 20715 GeneCards: UGT8
Gene location (Human)
Chr.	Chromosome 4 (human)
End	114,678,225 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	125,732,268 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; corpus callosum; ; subthalamic nucleus; ; superior vestibular nucleus; ; pons; ; external globus pallidus; ; ventral tegmental area; ; trigeminal ganglion; ; middle frontal gyrus; ; internal globus pallidus;
	Top expressed in
	pontine nuclei; ; ventral tegmental area; ; lateral geniculate nucleus; ; globus pallidus; ; dorsal tegmental nucleus; ; substantia nigra; ; lateral hypothalamus; ; medial geniculate nucleus; ; medial vestibular nucleus; ; mammillary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	hexosyltransferase activity; glycosyltransferase activity; glucuronosyltransferase activity; transferase activity; N-acylsphingosine galactosyltransferase activity; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; plasma membrane;
Biological process	lipid metabolism; neuron projection morphogenesis; galactosylceramide biosynthetic process; glycosphingolipid metabolic process; peripheral nervous system development; central nervous system development; paranodal junction assembly; metabolism; protein localization to paranode region of axon; cytoskeleton organization; sphingolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	7368
	22239
	ENSG00000174607
	ENSMUSG00000032854
	Q16880
	Q64676
	NM_001128174; NM_003360; NM_001322112; NM_001322113; NM_001322114
	NM_011674
	NP_001121646; NP_001309041; NP_001309042; NP_001309043; NP_003351
	NP_035804
	Wikidata
View/Edit Human	View/Edit Mouse

2-hydroxyacylsphingosine 1-beta-galactosyltransferase is an enzyme that in humans is encoded by the UGT8 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174607 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032854 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bosio A, Binczek E, Le Beau MM, Fernald AA, Stoffel W (Dec 1996). "The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): cloning, characterization, and assignment to human chromosome 4, band q26". Genomics. 34 (1): 69–75. doi:10.1006/geno.1996.0242. PMID 8661025.
^ "Entrez Gene: UGT8 UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174607 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032854 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8661025-5] Bosio A, Binczek E, Le Beau MM, Fernald AA, Stoffel W (Dec 1996). "The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): cloning, characterization, and assignment to human chromosome 4, band q26". Genomics. 34 (1): 69–75. doi:10.1006/geno.1996.0242. PMID 8661025.

[entrez-6] "Entrez Gene: UGT8 UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase)".

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