UGT1A6 information

UGT1A6
Identifiers
Aliases	UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT 1-6, UGT1, UGT1A6S, UGT1F, UDP glucuronosyltransferase family 1 member A6, UGT1.5, hUG-BR1, UGT1.3, UGT-1C, UGT1A, UGT1E, UGT-1A, UGT-1E, UGT1A3, UGT1A1, UGT1A5, UGT1-01, UGT1C, UGT1-05, UGT1-03, UGT1.1, UGT1.6, UGT1-06, UGT-1F
External IDs	OMIM: 606431; MGI: 3580629; HomoloGene: 85959; GeneCards: UGT1A6; OMA:UGT1A6 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,773,300 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,146,725 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; human kidney; ; testicle; ; olfactory zone of nasal mucosa; ; urinary bladder; ; skin of abdomen; ; skin of leg; ; duodenum; ; renal cortex;
	Top expressed in
	urinary bladder; ; white adipose tissue; ; exocrine gland; ; hepatobiliary system; ; liver; ; kidney tubule; ; proximal tubule; ; lateral recess; ; renal medulla; ; loop of Henle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; retinoic acid binding; hexosyltransferase activity; protein homodimerization activity; glycosyltransferase activity; protein heterodimerization activity; enzyme binding; glucuronosyltransferase activity; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum;
Biological process	negative regulation of cellular glucuronidation; cellular glucuronidation; xenobiotic glucuronidation; metabolism; negative regulation of glucuronosyltransferase activity; negative regulation of fatty acid metabolic process; xenobiotic metabolic process; flavonoid glucuronidation;
	Sources:Amigo / QuickGO
Orthologs
	54578
	394435
	ENSG00000167165
	ENSMUSG00000090145
	P19224
	K9J7B2
	NM_205862; NM_001072
	NM_201410
	NP_001063; NP_995584
	NP_958812
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 1-6 is an enzyme that in humans is encoded by the UGT1A6 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167165 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090145 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.
^ Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (February 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". The Journal of Biological Chemistry. 267 (5): 3257–61. doi:10.1016/S0021-9258(19)50724-4. PMID 1339448.
^ "Entrez Gene: UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167165 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000090145 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9295054-5] Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.

[pmid1339448-6] Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (February 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". The Journal of Biological Chemistry. 267 (5): 3257–61. doi:10.1016/S0021-9258(19)50724-4. PMID 1339448.

[entrez-7] "Entrez Gene: UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6".

UGT1A6 information

and 12 Related for: UGT1A6 information

UGT1A6

Glucuronosyltransferase

Allethrins

Cypermethrin

Desloratadine

Paracetamol

Bromazolam

Ferric maltol

Valproate

NFE2L2

Naturally occurring phenols

Sean Ekins