positive regulation of reciprocal meiotic recombination
protein stabilization
protein polyubiquitination
negative regulation of apoptotic process
in utero embryonic development
protein monoubiquitination
sperm axoneme assembly
cellular response to DNA damage stimulus
protein K11-linked ubiquitination
histone lysine demethylation
protein K48-linked ubiquitination
regulation of histone modification
spermatogenesis
canonical Wnt signaling pathway
synaptonemal complex organization
response to UV
proteasome-mediated ubiquitin-dependent protein catabolic process
protein autoubiquitination
DNA repair
protein ubiquitination
positive regulation of canonical Wnt signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7320
22210
Ensembl
ENSG00000119048
ENSMUSG00000020390
UniProt
P63146
P63147
RefSeq (mRNA)
NM_003337
NM_009458 NM_001362685 NM_001362686
RefSeq (protein)
NP_003328
NP_033484 NP_001349614 NP_001349615
Location (UCSC)
Chr 5: 134.37 – 134.39 Mb
Chr 11: 51.88 – 51.89 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene.[5][6]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000119048 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020390 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Koken MH, Smit EM, Jaspers-Dekker I, Oostra BA, Hagemeijer A, Bootsma D, Hoeijmakers JH (May 1992). "Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31". Genomics. 12 (3): 447–53. doi:10.1016/0888-7543(92)90433-S. hdl:1765/3036. PMID 1559696.
Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene. The modification of proteins with ubiquitin is an important cellular...
hypersensitivity to multiple mutagens. RAD18 has been shown to interact with HLTF, UBE2B and UBE2A. GRCh38: Ensembl release 89: ENSG00000070950 – Ensembl, May 2017...
Dery MA, Squair DR, Wood NT, Lamoliatte F, Lange SM, Virdee S. UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4. Nat Struct Mol Biol|...