negative regulation of type I interferon production
ISG15-protein conjugation
protein ubiquitination
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
protein modification by small protein conjugation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7318
74153
Ensembl
ENSG00000182179
ENSMUSG00000032596
UniProt
P41226
n/a
RefSeq (mRNA)
NM_003335
NM_023738
RefSeq (protein)
NP_003326
n/a
Location (UCSC)
Chr 3: 49.81 – 49.81 Mb
Chr 9: 107.85 – 107.86 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.[5][6]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000182179 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032596 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme". Proc Natl Acad Sci U S A. 90 (13): 6071–5. Bibcode:1993PNAS...90.6071K. doi:10.1073/pnas.90.13.6071. PMC 46869. PMID 8327486.
catalyzed by a series of conjugating enzymes. The activating E1 enzyme (UBE1L) charges ISG15 by forming a high-energy thiolester intermediate and transfers...
et al. (2004). "Identification and characteristics of a novel E1 like gene nUBE1L in human testis". Acta Biochim. Biophys. Sin. (Shanghai). 36 (3): 227–34...