The tubby protein is encoded by the TUB gene. It is an upstream cell signaling protein common to multicellular eukaryotes. The first tubby gene was identified in mice, and proteins that are homologous to tubby are known as "tubby-like proteins" (TULPs). They share a common and characteristic tertiary structure that consists of a beta barrel packed around an alpha helix in the central pore. The gene derives its name from its role in metabolism; mice with a mutated tubby gene develop delayed-onset obesity, sensorineural hearing loss, and retinal degeneration.[1][2][3]
^Noben-Trauth, K.; Naggert, J. K.; North, M. A.; Nishina, P. M. (1996). "A candidate gene for the mouse mutation tubby". Nature. 380 (6574): 534–538. Bibcode:1996Natur.380..534N. doi:10.1038/380534a0. PMID 8606774. S2CID 4272027.
^Kleyn, P. W.; Fan, W.; Kovats, S. G.; Lee, J. J.; Pulido, J. C.; Wu, Y.; Berkemeier, L. R.; Misumi, D. J.; Holmgren, L.; Charlat, O.; Woolf, E. A.; Tayber, O.; Brody, T.; Shu, P.; Hawkins, F.; Kennedy, B.; Baldini, L.; Ebeling, C.; Alperin, G. D.; Deeds, J.; Lakey, N. D.; Culpepper, J.; Chen, H.; Glücksmann-Kuis, M. A.; Carlson, G. A.; Duyk, G. M.; Moore, K. J. (1996). "Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family". Cell. 85 (2): 281–290. doi:10.1016/S0092-8674(00)81104-6. PMID 8612280. S2CID 15670925.
^Ohlemiller, KK; Hughes, RM; Mosinger-Ogilvie, J; Speck, JD; Grosof, DH; Silverman, MS (1995). "Cochlear and retinal degeneration in the tubby mouse". NeuroReport. 6 (6): 845–9. doi:10.1097/00001756-199504190-00005. PMID 7612867. S2CID 8311280.
The tubbyprotein is encoded by the TUB gene. It is an upstream cell signaling protein common to multicellular eukaryotes. The first tubby gene was identified...
Look up tubby in Wiktionary, the free dictionary. Tubby is a nickname and surname and may refer to: Tubby Clayton (1885–1972), Anglican clergyman, founder...
diagrams, are 3D schematic representations of protein structure and are one of the most common methods of protein depiction used today. The ribbon depicts...
surrounding a central alpha helix. This structure shows similarity to the Tubbyprotein. The enzymatic activity of scramblase depends on the calcium concentration...
Peripheral membrane proteins, or extrinsic membrane proteins, are membrane proteins that adhere only temporarily to the biological membrane with which...
Shan, W. S.; Myszka, D. G.; Shapiro, L. (2001-06-15). "G-protein signaling through tubbyproteins". Science. 292 (5524): 2041–2050. doi:10.1126/science.1061233...
transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA...
Tubby-related protein 1 is a protein that in humans is encoded by the TULP1 gene. TULP1 is a member of a family of tubby-like genes (TULPs) that encode...
called Beyond Meat. Beyond Meat is made of a blend of fava bean protein, pea protein, flours, and fiber. In July 2013, Tropical Smoothie Cafe announced...
2015. As part of a publicity stunt, Wayback offered milkshakes made with protein powder derived from crickets in June 2015 as part of a limited-time offer...
saturated fat, 1,443 milligrams (22.27 gr) of sodium, and 28 net grams of protein.[citation needed] In September 2020, Popeyes' chicken sandwich went on...
pianist Joseph Hoo Kim, record producer Diana King, reggae musician King Tubby, dub musician Sean Kingston, singer Sean Paul, singer Kiprich, DJ DJ Kool...
new protein option at selected locations in the Kansas City area. Some food writers have expressed their health related concerns over the protein's relatively...
Tubulin beta-2A chain is a protein that in humans is encoded by the TUBB2A gene. GRCh38: Ensembl release 89: ENSG00000137267 – Ensembl, May 2017 GRCm38:...
cause obesity, retinal degeneration and hearing loss in tubby mice. In the wild-type form, the protein Mtap1a, encoded by neuronally-expressed moth1, is protective...
keeping it double-stranded so that it cannot be transcribed into viral proteins. The precise mechanism by which double-stranded RNA is maintained is not...
Waterlow was inspired by a lecture about Leprosy in West Africa given by Tubby Clayton. Consequently, he went on to study natural sciences at Trinity College...
Champion; Currently a leader of The Judgment Day Alex Ramos (born 1961) – boxer Tubby Raskin (1902–1981) – basketball player and coach T. J. Rivera (born 1988)...
structure to "all-inclusive", in which the price only depended on the type of protein ($7.80 for chicken or vegetarian items and $8.40 for steak, shredded beef...
modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record...
stores by 2020. Panera also announced the addition of more plant-based proteins, such as edamame and organic quinoa, to its menu. At the time of the announcement...
Global Information