Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound
Tris, or tris(hydroxymethyl)aminomethane, or known during medical use as tromethamine or THAM, is an organic compound with the formula (HOCH2)3CNH2. It is extensively used in biochemistry and molecular biology as a component of buffer solutions[2] such as in TAE and TBE buffers, especially for solutions of nucleic acids. It contains a primary amine and thus undergoes the reactions associated with typical amines, e.g., condensations with aldehydes. Tris also complexes with metal ions in solution.[3] In medicine, tromethamine is occasionally used as a drug, given in intensive care for its properties as a buffer for the treatment of severe metabolic acidosis in specific circumstances.[4][5] Some medications are formulated as the "tromethamine salt" including Hemabate (carboprost as trometamol salt), and "ketorolac trometamol".[6] In 2023 a strain of Pseudomonas hunanensis was found to be able to degrade TRIS buffer.[7]
^"Tromethamine". pubchem.ncbi.nlm.nih.gov.
^Gomori, G., Preparation of Buffers for Use in Enzyme Studies. Methods Enzymology., 1, 138-146 (1955).
^FISCHER, Beda E.; HARING, Ulrich K.; TRIBOLET, Roger; SIGEL, Helmut (1979). "Metal Ion/Buffer Interactions. Stability of Binary and Ternary Complexes Containing 2-Amino-2(hydroxymethyl)-1,3-propanediol (Tris) and Adenosine 5'-Triphosphate (ATP)". European Journal of Biochemistry. 94 (2). Wiley: 523–530. doi:10.1111/j.1432-1033.1979.tb12921.x. ISSN 0014-2956. PMID 428398.
^Stanley, David; Tunnicliffe, William (June 2008). "Management of life-threatening asthma in adults". Continuing Education in Anaesthesia, Critical Care & Pain. 8 (3): 95–99. doi:10.1093/bjaceaccp/mkn012. Retrieved 21 July 2017.
^Hoste, Eric A.; Colpaert, Kirsten; Vanholder, Raymond C.; Lameire, Norbert H.; De Waele, Jan J.; Blot, Stijn I.; Colardyn, Francis A. (May 2005). "Sodium bicarbonate versus THAM in ICU patients with mild metabolic acidosis". Journal of Nephrology. 18 (3): 303–307. ISSN 1121-8428. PMID 16013019.
^BNF 73 March-September 2017. British Medical Association,, Royal Pharmaceutical Society of Great Britain. London. 21 March 2017. ISBN 978-0857112767. OCLC 988086079.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
^Holert, Johannes; Borker, Aron; Nübel, Laura Lucia; Daniel, Rolf; Poehlein, Anja; Philipp, Bodo (8 January 2024). "Bacteria use a catabolic patchwork pathway of apparently recent origin for degradation of the synthetic buffer compound TRIS". The ISME Journal. 18 (1): wrad023. doi:10.1093/ismejo/wrad023. ISSN 1751-7362.
Tris, or tris(hydroxymethyl)aminomethane, or known during medical use as tromethamine or THAM, is an organic compound with the formula (HOCH2)3CNH2. It...
Look up tri or tri- in Wiktionary, the free dictionary. Tri- is a numerical prefix meaning three. Tri or TRI may also refer to: Tri-Cities Regional Airport...
(2007). Tris Speaker: The Rough-and-Tumble Life of a Baseball Legend. Globe Pequot Press. ISBN 978-1599211114. Jensen, Don. "Tris Speaker". SABR. Tris Speaker...
Tris's room but later gets caught and beaten up by Tris. During the Erudite and Dauntless traitors' attack on Amity, Tris saves his life. When Tris surrenders...
Paiste cymbals Vic Firth drumsticks Beato Bags Latin Percussion "Tris Imboden: Gigs". Tris Imboden. Archived from the original on December 10, 2013. Retrieved...
the wake of the uprising, Tris and Four are on the run. Hunted by Jeanine Matthews, the leader of the Erudite faction, Tris and Four race against time...
TBE or Tris/Borate/EDTA, is a buffer solution containing a mixture of Tris base, boric acid and EDTA. In molecular biology, TBE and TAE buffers are often...
articles, technical reports and the media. The TRIS Database returned to TRB in 2010; in 2011 the TRIS Database was integrated with other international...
composed of 10 mM Tris-HCl (pH 8.0) + 0.1 mM EDTA. LB buffer, lithium borate buffer, a similar buffer containing lithium ions in place of Tris TAE buffer and...