Transcranial pulsed ultrasound (TPU) uses low intensity, low frequency ultrasound (LILFU) to stimulate the brain. In 2002, Dr. Alexander Bystritsky first proposed the idea that this methodology contained therapeutic benefits.[1] Beginning in 2008, Dr. William Tyler and his research team from Arizona State University began an investigation and development of this alternative neuromodulation without the harmful effects and risks of invasive surgery. They discovered that this low-power ultrasound is able to stimulate high neuron activity which allows for the manipulation of the brain waves through an external source. Unlike deep brain stimulation or Vagus nerve stimulation, which use implants and electrical impulses, TPU is a noninvasive and focused procedure that does not require the implantation of electrodes that could damage the nervous tissue. Its use is applicable in the various fields including but not limited to medical and military science. Although this technology holds great potential to introducing new and beneficial alternatives to conventional brain manipulation, it is a relatively young science and has certain obstructions to its full development such as a lack of complete understanding and control of every safety measure.[2]
^Hameroff, Stewart (2013). "Transcranial ultrasound (TUS) effects on mental states: A pilot study" (PDF). Brain Stimulation. 6 (3). Elsevier: 409–15. doi:10.1016/j.brs.2012.05.002. PMID 22664271. S2CID 206354818. Archived from the original (PDF) on 22 March 2013. Retrieved 25 October 2013.
^"Ultrasound Shown To Exert Remote Control Of Brain Circuits". ScienceDaily. Brain Circuits. Retrieved 23 October 2013.
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