Topoisomers or topological isomers are molecules with the same chemical formula and stereochemical bond connectivities but different topologies. Examples of molecules for which there exist topoisomers include DNA, which can form knots, and catenanes. Each topoisomer of a given DNA molecule possesses a different linking number associated with it. DNA topoisomers can be interchanged by enzymes called topoisomerases.[1] Using a topoisomerase along with an intercalator, topoisomers with different linking number may be separated on an agarose gel via gel electrophoresis.
Three topoisomers of a closed circular DNA molecule. Left: negatively supercoiled; center: relaxed; right: positively supercoiled
Topoisomers or topological isomers are molecules with the same chemical formula and stereochemical bond connectivities but different topologies. Examples...
mirror-image enantiomer pairs. Such forms are called topological isomers or topoisomers. Also, two or more such molecules may be bound together in a catenane...
geometric topology topics List of topology topics Publications in topology Topoisomer Topology glossary Topological Galois theory Topological geometry Topological...
isomers (or regioisomers), functional isomers, tautomers, and structural topoisomers. A skeletal isomer of a compound is a structural isomer that differs...
terms of a helical model for DNA, but in 2008 it was noted that each topoisomer, negative or positive, adopts a unique and surprisingly wide distribution...
this. More generally, knot theoretic methods have been used in studying topoisomers, topologically different arrangements of the same chemical formula. The...
Development of ethidium-agarose electrophoresis (5) (for the separation of DNA topoisomers); proof that linear DNA molecules move like snakes through the gel (5)...
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