Tideglusib information

Tideglusib
Identifiers
	IUPAC name 4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione;
CAS Number	865854-05-3;
PubChem CID	11313622;
ChemSpider	9488589;
UNII	Q747Y6TT42;
ChEBI	CHEBI:147398;
CompTox Dashboard (EPA)	DTXSID90235682 ;
Chemical and physical data
Formula	C19H14N2O2S
Molar mass	334.39 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C3SN(c1cccc2c1cccc2)C(=O)N3Cc4ccccc4;
	InChI InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2;

Tideglusib (NP-12, NP031112) is a potent and irreversible^[1] small molecule glycogen synthase kinase 3 (GSK-3) inhibitor.

^ Domínguez JM, Fuertes A, Orozco L, del Monte-Millán M, Delgado E, Medina M (January 2012). "Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib". The Journal of Biological Chemistry. 287 (2): 893–904. doi:10.1074/jbc.M111.306472. PMC 3256883. PMID 22102280.

and 2 Related for: Tideglusib information

Identifiers


IUPAC name 4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione
CAS Number	865854-05-3
PubChem CID	11313622
ChemSpider	9488589
UNII	Q747Y6TT42
ChEBI	CHEBI:147398
CompTox Dashboard (EPA)	DTXSID90235682
Chemical and physical data
Formula	C₁₉H₁₄N₂O₂S
Molar mass	334.39 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C3SN(c1cccc2c1cccc2)C(=O)N3Cc4ccccc4
InChI InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2