Global InformationTetracenomycin C information
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| IUPAC name
Methyl (6aR,7S,10aR)-6a,7,10a,12-tetrahydroxy-3,8-dimethoxy-1-methyl-6,10,11-trioxo-6,6a,7,10,10a,11-hexahydrotetracene-2-carboxylate
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| Identifiers | |
CAS Number
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3D model (JSmol)
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Beilstein Reference
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4774234 |
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PubChem CID
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InChI
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SMILES
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| Properties | |
Chemical formula
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C23H20O11 |
| Molar mass | 472.402 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
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Tetracenomycin C is an antitumor anthracycline-like antibiotic produced by Streptomyces glaucescens GLA.0.[1] The pale-yellow antibiotic is active against some gram-positive bacteria, especially against streptomycetes. Gram-negative bacteria and fungi are not inhibited. In considering the differences of biological activity and the functional groups of the molecule, tetracenomycin C is not a member of the tetracycline or anthracyclinone group of antibiotics.[2] Tetracenomycin C is notable for its broad activity against actinomycetes. As in other anthracycline antibiotics, the framework is synthesized by a polyketide synthase and subsequently modified by other enzymes.
- ^ Weber, W; Zahner, H; Siebers, J; Schroder, K; Zeeck, A (1979). "Metabolic products of microorganisms". Arch. Microbiol. 121 (2): 111–116. doi:10.1007/bf00689973. PMID 485765. S2CID 32884198.
- ^ Weber, W; Zahner, H; Siebers, J; Schroder, K; Zeeck, A (1979). "Proceeding of the fourth International Symposium on the Actinomycete Biology". Actinomycetes: 465.