Protein-coding gene in the species Homo sapiens
TTBK1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BTJ, 4BTK, 4BTM, 4NFM, 4NFN
Identifiers Aliases TTBK1 , BDTK, tau tubulin kinase 1External IDs MGI: 2147036 HomoloGene: 50342 GeneCards: TTBK1 Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 43,243,481 bp[1] End 43,288,258 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 46,753,374 bp[2] End 46,798,601 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex postcentral gyrus superior frontal gyrus entorhinal cortex Brodmann area 9 amygdala nucleus accumbens putamen ventral tegmental area pons
Top expressed in superior frontal gyrus seminiferous tubule cerebellar cortex primary motor cortex cingulate gyrus spermatid subiculum spermatocyte hippocampus proper pontine nuclei
More reference expression data
BioGPS
Gene ontology Molecular function
transferase activity
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
ATP binding
kinase activity
tau protein binding
tau-protein kinase activity Cellular component
cytoplasm
nucleus
nucleoplasm
cytosol
microtubule associated complex
neuronal cell body
perinuclear region of cytoplasm Biological process
protein phosphorylation
peptidyl-serine phosphorylation
substantia nigra development
phosphorylation
regulation of cell shape
learning or memory
positive regulation of gene expression
negative regulation of gene expression
peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
negative regulation of protein binding
positive regulation of protein polymerization
positive regulation of astrocyte activation
positive regulation of microglial cell activation
positive regulation of cyclin-dependent protein kinase activity
positive regulation of cysteine-type endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 6: 43.24 – 43.29 Mb Chr 17: 46.75 – 46.8 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Tau tubulin kinase 1 is a protein that in humans is encoded by the TTBK1 gene.[5]
^ a b c GRCh38: Ensembl release 89: ENSG00000146216 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015599 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^
"Entrez Gene: Tau tubulin kinase 1". Retrieved 2017-03-23 .
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