TRIM63 information

TRIM63
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DDT, 4M3L, 2D8U
Identifiers
Aliases	TRIM63, IRF, MURF1, MURF2, RNF28, SMRZ, tripartite motif containing 63
External IDs	OMIM: 606131 MGI: 2447992 HomoloGene: 41878 GeneCards: TRIM63
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,068,436 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	134,056,940 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; tibialis anterior muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; deltoid muscle; ; biceps brachii; ; right ventricle; ; body of tongue; ; vena cava; ; superior surface of tongue;
	Top expressed in
	knee joint; ; tibialis anterior muscle; ; triceps brachii muscle; ; soleus muscle; ; vastus lateralis muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; digastric muscle; ; intercostal muscle; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; protein binding; titin binding; signal transducer activity; metal ion binding; ubiquitin-protein transferase activity; transferase activity;
Cellular component	cytoplasm; M band; contractile fiber; Z disc; microtubule; nucleus; intracellular anatomical structure;
Biological process	skeletal muscle atrophy; muscle contraction; response to glucocorticoid; response to interleukin-1; protein ubiquitination; response to electrical stimulus involved in regulation of muscle adaptation; signal transduction; negative regulation of cardiac muscle hypertrophy;
	Sources:Amigo / QuickGO
Orthologs
	84676
	433766
	ENSG00000158022
	ENSMUSG00000028834
	Q969Q1
	Q38HM4
	NM_032588
	NM_001039048; NM_001369245
	NP_115977
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase TRIM63, also known as "MuRF1" (Muscle Ring-Finger Protein-1),^[5] is an enzyme that in humans is encoded by the TRIM63 gene.^[6]^[7]^[8]

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.^[8]

The protein encoded by the Trim63 gene is also called MuRF1. MuRF1 is the name most commonly used in the literature, and it stands for "Muscle RING Finger 1." Structurally, there are two closely related MuRFs, MuRF2 and MuRF3. These also have TRIM codes: MuRF2 is TRIM55; MuRF3 is TRIM54.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158022 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028834 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ (November 2001). "Identification of ubiquitin ligases required for skeletal muscle atrophy". Science. 294 (5547): 1704–1708. Bibcode:2001Sci...294.1704B. doi:10.1126/science.1065874. PMID 11679633. S2CID 37349291.
^ Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S (March 2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain". Journal of Molecular Biology. 306 (4): 717–726. doi:10.1006/jmbi.2001.4448. PMID 11243782.
^ Dai KS, Liew CC (June 2001). "A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain". The Journal of Biological Chemistry. 276 (26): 23992–23999. doi:10.1074/jbc.M011208200. PMID 11283016.
^ ^a ^b "Entrez Gene: TRIM63 tripartite motif-containing 63".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158022 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028834 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11679633-5] Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ (November 2001). "Identification of ubiquitin ligases required for skeletal muscle atrophy". Science. 294 (5547): 1704–1708. Bibcode:2001Sci...294.1704B. doi:10.1126/science.1065874. PMID 11679633. S2CID 37349291.

[pmid11243782-6] Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S (March 2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain". Journal of Molecular Biology. 306 (4): 717–726. doi:10.1006/jmbi.2001.4448. PMID 11243782.

[pmid11283016-7] Dai KS, Liew CC (June 2001). "A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain". The Journal of Biological Chemistry. 276 (26): 23992–23999. doi:10.1074/jbc.M011208200. PMID 11283016.

[entrez-8] "Entrez Gene: TRIM63 tripartite motif-containing 63".

TRIM63 information

and 6 Related for: TRIM63 information

TRIM63

Titin

RING finger domain

Tripartite motif family

SUMO2

GMEB1