Transmembrane protein 39B (TMEM39B) is a protein that in humans is encoded by the gene TMEM39B.[1] TMEM39B is a multi-pass membrane protein with eight transmembrane domains.[1] The protein localizes to the plasma membrane and vesicles.[1][2] The precise function of TMEM39B is not yet well-understood by the scientific community, but differential expression is associated with survival of B cell lymphoma, and knockdown of TMEM39B is associated with decreased autophagy in cells infected with the Sindbis virus.[3][4] Furthermore, the TMEM39B protein been found to interact with the SARS-CoV-2 ORF9C (also known as ORF14) protein.[5] TMEM39B is expressed at moderate levels in most tissues, with higher expression in the testis, placenta, white blood cells, adrenal gland, thymus, and fetal brain.[6][7]
^ abc"TMEM39B transmembrane protein 39B [ Homo sapiens (human) ]". National Center for Biotechnology Information. U.S. National Library of Medicine. Retrieved 11 June 2020.
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^Gordon, David E.; Jang, Gwendolyn M.; Bouhaddou, Mehdi; Xu, Jiewei; Obernier, Kirsten; White, Kris M.; O’Meara, Matthew J.; Rezelj, Veronica V.; Guo, Jeffrey Z.; Swaney, Danielle L.; Tummino, Tia A. (2020-04-30). "A SARS-CoV-2 protein interaction map reveals targets for drug repurposing". Nature. 583 (7816): 459–468. Bibcode:2020Natur.583..459G. doi:10.1038/s41586-020-2286-9. ISSN 1476-4687. PMC 7431030. PMID 32353859.
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Transmembrane protein 39B (TMEM39B) is a protein that in humans is encoded by the gene TMEM39B. TMEM39B is a multi-pass membrane protein with eight transmembrane...
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