TMEM38A information

TMEM38A
Identifiers
Aliases	TMEM38A, TRIC-A, TRICA, transmembrane protein 38A
External IDs	OMIM: 611235; MGI: 1921416; HomoloGene: 11449; GeneCards: TMEM38A; OMA:TMEM38A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	16,690,023 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	72,587,282 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; skeletal muscle tissue; ; tibialis anterior muscle; ; Skeletal muscle tissue of rectus abdominis; ; deltoid muscle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	interventricular septum; ; muscle of thigh; ; skeletal muscle tissue; ; medial head of gastrocnemius muscle; ; triceps brachii muscle; ; quadriceps femoris muscle; ; tibialis anterior muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; vastus lateralis muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	potassium channel activity; cation channel activity; calcium-activated potassium channel activity;
Cellular component	sarcoplasmic reticulum; integral component of membrane; nuclear membrane; extracellular exosome; membrane; sarcoplasmic reticulum membrane; nucleus;
Biological process	potassium ion transport; ion transport; potassium ion transmembrane transport; transport; endoplasmic reticulum organization; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; protein homotrimerization; cellular response to caffeine;
	Sources:Amigo / QuickGO
Orthologs
	79041
	74166
	ENSG00000072954
	ENSMUSG00000031791
	Q9H6F2
	Q3TMP8
	NM_024074
	NM_144534
	NP_076979
	NP_653117; NP_001344207; NP_001344208; NP_001344209; NP_001344213
	Wikidata
View/Edit Human	View/Edit Mouse

Trimeric intracellular cation-selective channel A (TRIC-A) is a monovalent cation channel in the SR and nuclear membranes of skeletal muscle cells,^[5]^[6] encoded by the transmembrane protein 38A (TMEM38A) gene. It is one of two known TRIC proteins, the other being TRIC-B.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072954 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031791 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Venturi, Elisa; Sitsapesan, Rebecca; Yamazaki, Daiju; Takeshima, Hiroshi (15 December 2012). "TRIC channels supporting efficient Ca2+ release from intracellular stores". European Journal of Physiology. 465 (2): 187–195. doi:10.1007/s00424-012-1197-5. PMID 23242030. S2CID 14397400.
^ Cabral, Wayne A.; Ishikawa, Masaki; Garten, Matthias; Makareeva, Elena N.; Sargent, Brandi M.; Weis, MaryAnn; Barnes, Aileen M.; Webb, Emma A.; Shaw, Nicholas J.; Ala-Kokko, Leena; Lacbawan, Felicitas L.; Högler, Wolfgang; Leikin, Sergey; Blank, Paul S.; Zimmerberg, Joshua; Eyre, David R.; Yamada, Yoshihiko; Marini, Joan C. (21 July 2016). "Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta". PLOS Genetics. 12 (7): e1006156. doi:10.1371/journal.pgen.1006156. PMC 4956114. PMID 27441836.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072954 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031791 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[venturi-5] Venturi, Elisa; Sitsapesan, Rebecca; Yamazaki, Daiju; Takeshima, Hiroshi (15 December 2012). "TRIC channels supporting efficient Ca2+ release from intracellular stores". European Journal of Physiology. 465 (2): 187–195. doi:10.1007/s00424-012-1197-5. PMID 23242030. S2CID 14397400.

[cabral2016-6] Cabral, Wayne A.; Ishikawa, Masaki; Garten, Matthias; Makareeva, Elena N.; Sargent, Brandi M.; Weis, MaryAnn; Barnes, Aileen M.; Webb, Emma A.; Shaw, Nicholas J.; Ala-Kokko, Leena; Lacbawan, Felicitas L.; Högler, Wolfgang; Leikin, Sergey; Blank, Paul S.; Zimmerberg, Joshua; Eyre, David R.; Yamada, Yoshihiko; Marini, Joan C. (21 July 2016). "Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta". PLOS Genetics. 12 (7): e1006156. doi:10.1371/journal.pgen.1006156. PMC 4956114. PMID 27441836.