TLN2 information

TLN2
Identifiers
Aliases	TLN2, ILWEQ, talin 2
External IDs	OMIM: 607349; MGI: 1917799; HomoloGene: 56692; GeneCards: TLN2; OMA:TLN2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	62,844,631 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	67,466,985 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; middle temporal gyrus; ; frontal pole; ; Brodmann area 46; ; orbitofrontal cortex; ; Brodmann area 10; ; Achilles tendon; ; ventricular zone; ; Brodmann area 23; ; Region I of hippocampus proper;
	Top expressed in
	tail of embryo; ; spermatid; ; seminiferous tubule; ; superior cervical ganglion; ; medial dorsal nucleus; ; medial head of gastrocnemius muscle; ; ankle; ; human kidney; ; genital tubercle; ; soleus muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin binding; actin filament binding; structural constituent of cytoskeleton; protein binding; structural molecule activity;
Cellular component	cytoplasm; ruffle; cell junction; plasma membrane; synapse; cytoskeleton; membrane; cell-cell junction; focal adhesion; actin cytoskeleton;
Biological process	cell adhesion; cell-cell junction assembly;
	Sources:Amigo / QuickGO
Orthologs
	83660
	70549
	ENSG00000171914
	ENSMUSG00000052698
	Q9Y4G6
	Q71LX4
	NM_015059; NM_001394547
	NM_001081242; NM_027458
	NP_055874
NP_001074711; NP_001395227; NP_001395228; NP_001395229; NP_001395230;
	NP_081734
	Wikidata
View/Edit Human	View/Edit Mouse

Talin-2 is a protein in humans that is encoded by the TLN2 gene. It belongs to the talin protein family. This gene encodes a protein related to talin-1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments. Talin-2 is expressed at high levels in cardiac muscle and functions to provide linkages between the extracellular matrix and actin cytoskeleton at costamere structures to transduce force laterally.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171914 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052698 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Talin 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171914 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052698 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Talin 2".