TANGO2 information

TANGO2
Identifiers
Aliases	TANGO2, C22orf25, MECRCN, transport and golgi organization 2 homolog
External IDs	OMIM: 616830; MGI: 101825; HomoloGene: 44029; GeneCards: TANGO2; OMA:TANGO2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	20,067,164 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; granulocyte; ; blood; ; monocyte; ; right auricle; ; myocardium of left ventricle; ; right lobe of thyroid gland; ; right coronary artery; ; left lobe of thyroid gland; ; spleen;
	n/a
	More reference expression data
	n/a
Orthologs
	128989
	27883
	ENSG00000183597
	ENSMUSG00000013539
	Q6ICL3
	P54797
NM_001283106; NM_001283116; NM_001283129; NM_001283148; NM_001283154;
	NM_001283179; NM_001283186; NM_001283199; NM_001283215; NM_001283235; NM_001283248; NM_152906; NM_001322141; NM_001322142; NM_001322143; NM_001322144; NM_001322145; NM_001322146; NM_001322147; NM_001322148; NM_001322149; NM_001322150; NM_001322153; NM_001322155; NM_001322160; NM_001322163; NM_001322166; NM_001322167; NM_001322169; NM_001322171; NM_001322172; NM_001322173; NM_001322174; NM_001322175
	NM_138583
NP_001270035; NP_001270045; NP_001270058; NP_001270077; NP_001270083;
	NP_001270108; NP_001270115; NP_001270128; NP_001270144; NP_001270164; NP_001270177; NP_001309070; NP_001309071; NP_001309072; NP_001309073; NP_001309074; NP_001309075; NP_001309076; NP_001309077; NP_001309078; NP_001309079; NP_001309082; NP_001309084; NP_001309089; NP_001309092; NP_001309095; NP_001309096; NP_001309098; NP_001309100; NP_001309101; NP_001309102; NP_001309103; NP_001309104; NP_690870
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Transport and golgi organization 2 homolog (TANGO2) also known as chromosome 22 open reading frame 25 (C22orf25) is a protein that in humans is encoded by the TANGO2 gene.

The function of C22orf25 is not currently known. It is characterized by the NRDE superfamily domain (DUF883), which is strictly known for the conserved amino acid sequence of (N)-Asparagine (R)-Arginine (D)-Aspartic Acid (E)-Glutamic Acid. This domain is found among distantly related species from the six kingdoms:^[4] Eubacteria, Archaebacteria, Protista, Fungi, Plantae, and Animalia and is known to be involved in Golgi organization and protein secretion.^[5] It is likely that it localizes in the cytoplasm but is anchored in the cell membrane by the second amino acid.^[6]^[7] C22orf25 is also xenologous to T10 like proteins in the Fowlpox Virus and Canarypox Virus. The gene coding for C22orf25 is located on chromosome 22 and the location q11.21, so it is often associated with 22q11.2 deletion syndrome.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183597 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "BLAST (NCBI)".
^ "Conserved Domains (NCBI)".
^ "CSS-Palm". Archived from the original on 2009-02-15. Retrieved 2012-05-08.
^ "PSORTII".
^ "Gene (NCBI)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183597 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "BLAST (NCBI)".

[5] "Conserved Domains (NCBI)".

[autogenerated2-6] "CSS-Palm". Archived from the original on 2009-02-15. Retrieved 2012-05-08.

[7] "PSORTII".

[autogenerated1-8] "Gene (NCBI)".

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