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Synthalin information


Synthalin
Skeletal formula of synthalin
Names
Preferred IUPAC name
N,N′′′-(Decane-1,10-diyl)diguanidine
Identifiers
CAS Number
  • 111-23-9 checkY
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:84338 checkY
ChEMBL
  • ChEMBL1194310 checkY
ChemSpider
  • 60335 ☒N
ECHA InfoCard 100.003.499 Edit this at Wikidata
EC Number
  • 203-848-1
MeSH synthalin+A
PubChem CID
  • 66977
UNII
  • ZEA6Y34XYT checkY
CompTox Dashboard (EPA)
  • DTXSID50911935 Edit this at Wikidata
InChI
  • InChI=1S/C12H28N6/c13-11(14)17-9-7-5-3-1-2-4-6-8-10-18-12(15)16/h1-10H2,(H4,13,14,17)(H4,15,16,18) checkY
    Key: OZZMUVKANAPKGI-UHFFFAOYSA-N checkY
SMILES
  • NC(=N)NCCCCCCCCCCNC(N)=N
Properties
Chemical formula
C12H28N6
Molar mass 256.398 g·mol−1
Pharmacology
Routes of
administration
Oral
Related compounds
Related compounds
  • Spermine
  • Arginylglycylaspartic acid
  • Dibutylhexamethylenediamine
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Synthalin was an oral anti-diabetic drug. Discovered in 1926 it was marketed in Europe by Schering AG of Berlin as a synthetic drug with insulin-like properties that could be taken orally. However, it was toxic to the liver and kidney and was withdrawn from the market in the early 1940s.

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Synthalin

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Synthalin was an oral anti-diabetic drug. Discovered in 1926 it was marketed in Europe by Schering AG of Berlin as a synthetic drug with insulin-like...

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Biguanide

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compounds lowered blood glucose levels. Some less toxic derivatives, synthalin A and synthalin B, were used for diabetes treatment, but after the discovery of...

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562 g·mol−1 Related compounds Related alkanamides Gusperimus Related compounds Synthalin Except where otherwise noted, data are given for materials in their standard...

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studied. This result was ignored, as other guanidine analogs such as the synthalins, took over and were themselves soon overshadowed by insulin. Interest...

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Dibutylhexamethylenediamine

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Flash point 113 °C (235 °F; 386 K) Related compounds Related compounds Synthalin Arginylglycylaspartic acid Gusperimus Except where otherwise noted, data...

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Karl Slotta

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then used to treat symptoms of diabetes. The synthetic, marketed as Synthalin, proved less toxic and more potent than prior plant products. Slotta was...

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